ORIGINAL RESEARCH
In vivo Antioxidant Potential of Raphanus sativus
Seeds in Rat Kidney Against CCl4-Induced Toxicity
1
Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, 45320, Pakistan
2
Department of Biosciences, COMSATS University Islamabad, 45550 Pakistan
3
School of Ecology and Environmental Science, Yunnan University, No. 2 North Cuihu Road,
Kunming, Yunnan, 650091, P.R. China
4
Department of Biological Sciences King Abdulaziz University, Jeddah 21589, Saudi Arabia
5
State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology,
Chinese Academy of Science, Beijing 100101, China
6
Department of Microbiology, University of Swabi, Ambar 23561, Pakistan.
7
Department of Microbiology, Cholistan University of Veterinary & Animal Sciences Bahawalpur 63100, Pakistan
8
Department of Entomology, the University of Agriculture Peshawar, Pakistan
9
Department of Bioinformatics and Biotechnology, International Islamic University Islamabad Pakistan
10
Departmemt of Radiology, Samsung Medical Center Irwon Dong Gangnam gu Seoul Korea
11
Department of Botany, University of Balochistan, Quetta, Pakistan
Submission date: 2018-04-26
Acceptance date: 2018-08-20
Online publication date: 2019-08-06
Publication date: 2019-10-23
Corresponding author
Muhammad Shuaib
School of Ecology and Environmental Science, Yunnan University, NO.2 North Cuihu road, Kunming, Yunnan, 650091, PR. China, School of Ecology and Environmental Science, Yunnan University, NO.2 North Cuihu road, Kunming, Yunn, 650091 Kunming, China
School of Ecology and Environmental Science, Yunnan University, NO.2 North Cuihu road, Kunming, Yunnan, 650091, PR. China, School of Ecology and Environmental Science, Yunnan University, NO.2 North Cuihu road, Kunming, Yunn, 650091 Kunming, China
Pol. J. Environ. Stud. 2020;29(1):277-284
KEYWORDS
TOPICS
ABSTRACT
In this study, the methanolic extract of Raphanus sativus (RSME) seeds was evaluated for
its protective effect against CCl4-induced nephrotoxicity. The treatment of Swiss albino rats with
intraperitoneal injections of CCl4 (1 ml/kg body weight) on alternate days for 30 days decreased the
antioxidant enzymes, while lipid peroxidation and serum toxicity markers were increased. These
changes were reversed in the animals receiving an oral dose of RSME (100 and 200 mg/kg body weight)
along with CCl4, thus increasing the level of antioxidant enzymes and decreasing serum toxicity markers
and thus ameliorating the toxic effect of CCl4. These results show that seed extract of R. sativus can
reciprocate the toxic effects of CCl4 and can be used to make a chemopreventive drug.
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| eISSN: | 2083-5906 |
| ISSN: | 1230-1485 |
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