Activity of Lysosomal Exoglycosidases of Rat Alimentary Tract in Chronic Exposure to N-Nitrosodimethylamine
Katarzyna Rostkowska1, Krzysztof Zwierz1, Leszek Piotr Arciuch1, Andrzej Różański2, Janina Moniuszko-Jakoniuk3, Alicja Roszczenko3
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1Department of Pharmaceutical Biochemistry, 2Department of Organic Chemistry and 3Department of Toxicology, Medical Academy in Bialystok, Adama Mickiewicza 2a, 15-222 Białystok, Poland
Pol. J. Environ. Stud. 1998;7(5):313–316
There is observed increasing pollution of environment by nitrosocompounds. Acute intoxication of animals by nitrosocompounds lead to necrosis and chronic exposure to neoplasm. We have little information on the influence of nitrosocompounds on metabolism of glycoconjugates (glycoproteins, glycolipids and proteoglycans) in animals. The aim of our work is evaluation the influence of exposure of rats for 10 and 90 days to N-nitrosodimethylamine (NDMA), on activity of lysosomal exoglycosidases (enzymes hydrolysing terminal sugars in oligosaccharides) in the alimentary tract. It was found that intoxication of rats with NDMA increased specific activity of N-acetyl-b-hexosaminidase, b-galactosidase and a-mannosidase in majority of tissues of rat alimentary tract. Damage the cells of alimentary tract by NDMA or its metabolites, increase activity of exoglycosidases, because damaged tissue elements must be removed by catabolic enzymes before restoration processes can start.