Concentration of Porphyrins in Rat Liver and Kidneys after Repeated Administration of Hexabromobenzene and Tetrabromobisphenol-A
B. Frydrych, J. A. Szymanska, A. Swiderska-Comer
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Department of Toxicology, Faculty of Pharmacy Medical University of Łódź, Łódź, Poland
Pol. J. Environ. Stud. 2006;15(4):543-548
The aim of this study was to complete research on the porphyrogenic effect of hexabrombenzene (HBB) and tetrabromobisphenol-A (TBBP-A).
Experiments were performed on female Wistar rats. The examined compounds were administered in sunflower oil intragastrically in 3 doses. The determination of porphyrins in tissues was carried out by means of high-performance liquid chromatography.
Repeated HBB administration caused a 3-8 times increase of total concentration of high carboxylated porphyrins (octa- and heptacarboxyporphyrins). The concentrations of these porphyrins were significantly lower in the liver of rats exposed to TBBP-A. however, in the kidneys significant alterations in porphyrins concentrations concerned only HBB.
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