ORIGINAL RESEARCH
Effect of Gamma Irradiation on Intestinal Crypts Survival in Mice Pretreated with N-Nitrosodiethylamine
I.P. Grudziński
Department of Food Studies and Nutrition Physiology, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland
Pol. J. Environ. Stud. 2000;9(4):281–283
KEYWORDS
ABSTRACT
A new mathematical equation was developed by which whole-body exposure to gamma radiation may be used to predict the survival characteristic of the intestinal crypt in mice pretreated with N-nitrosodiethylamine (NDEA). A computer fitting procedure showed the best agreement between predicted and observed curves. The results suggest that less cells may survive in crypts after gamma irradiation of NDEA-treated mice.
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