Frequency of Polymorphisms in Gene-Coding Xenobiotic Metabolizing Enzymes and DNA Repair Proteins in Young, Healthy Polish Individuals
M. M. Sasiadek1, I. Laczmanska1, P. Karpinski1, J. Gil1, A. Trusewicz1, K. Pesz1, D. Ramsey2, N. Blin3
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1Department of Genetics, Wroclaw Medical University, Marcinkowskiego 1, 50-367 Wrocław, Poland
2School of Mathematics and Statistics, University of Limerick, Limerick, Ireland
3Division of Molecular Genetics, University of Tuebingen, Institute of Human Genetics, Wilhelmstr. 27, D-72074 Tuebingen, Germany
Pol. J. Environ. Stud. 2008;17(6):933–940
The association between polymorphism in both DNA repair and xenobiotic metabolism genes and cancer risk has been reported by many authors. Recent studies have revealed the genetic heterogeneity of various populations. Therefore, the aim of our study was to evaluate the frequency of selected polymorphisms/mutations in 17 minor susceptibility genes and to analyze the pattern of their distribution in a group of 146 healthy, young Polish individuals.The results of our study show that the distribution of studied polymorphisms displayed a distinct pattern.