ORIGINAL RESEARCH
Interaction of Organo-tin Derivatives with Gramicidin Ion-conducting Channel
H. Radecka
Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Division of Food Science, Tuwima 10, 10-747 Olsztyn, Poland
Pol. J. Environ. Stud. 2000;9(5):419–422
KEYWORDS
triphenyltin(IV) chloridetrimetyltin(IV) chlorideplanar lipid bilayersgramicidin ion-conducting channel
ABSTRACT
The objective of this study was to determine the interaction of organo tin (IV) compounds with a gramicidin ion-conducting channel incorporated into planar lipid bilayers. The relative change of trans membrane current was used as a parameter for estimation the above interaction. This measured parameter was in good relationship with physicochemical (logP) and topological (TSA) properties of the compounds under study. The presented model might be apply for estimation of toxicity of organo metallic derivatives.
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