The degradation of 2,4,6-Trinitroresorcinol (TNR) in aqueous solution by dielectric barrier discharge system was investigated and the effect of some factors that might affect the degradation process was also further examined. The results showed that TNR could be effectively removed from aqueous solution by cold plasma. Under the experimental conditions, the TNR removal efficiency was proportional to the input electric power and the circulating flow rate, but inversely proportional to the initial pH, initial concentration and electrode distance. Initial pH significantly influenced on the TNR removal efficiency. Accordingly, in acidic medium, the TNR removal efficiency was higher than that in neutral and alkaline medium and is highest at pH = 3.2. The presence of some oxidizing agents in the solution such as H₂O₂, Na₂S₂O₈, O₂ greatly increased the TNR removal efficiency under the effect of cold plasma. The TNR removal efficiency increased gradually by the range of plasma/H₂O₂ > plasma/O₂ > plasma/Na₂S₂O₈ > plasma. The TNR degradation process in the presence and absence of the oxidizing agents all abided by the regulation of first order reaction kinetics.