Metabolic Interactions in Rats Treated with Acetylsalicylic Acid and Trichloroethylene
B. Zielinska-Psuja, J. Orlowski, A. Plewka*, M. Kaminski*, J. Kowalowka-Zawieja, B. Zieba-Proc
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Department of Toxicology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
*Department of Histology & Embriology, Silesian School of Medicine, Katowice-Ligota, Poland
Pol. J. Environ. Stud. 1999;8(5):319-325
The influence of acetylsalicylic acid (ASA) on elimination of trichloroacetic acid and trichloroethanol in the urine and liver and kidney of cytochrome P-450-dependent monooxygenase systems in rats exposed to trichloroethylene (TRI) vapours were examined. The obtained results show that acetylsalicylic acid decreased the elimination of both trichloroethylene metabolites and induced cytochrome P-450 concentration in the liver, whereas slightly inhibited cytochrome b5 and activites of NADPH-cytochrome P-450 reductase and NADH-cytochrome b5 reductase. After mixed exposures, acetylsalicylic acid elevated cytochrome P-450 concentration and NADPH-cytochrome P-450 reductase activity to values observed in the control group. The concentration of cytochrome b5 was much lower than after ASA or trichloroethylene alone. The activity of NADPH-cytochrome P-450 reductase was strongly inhibited by TRI, whereas in ASA presence was elevated, but it was still lower than in control. Acetylsalicylic acid stimulates cytochrome P-450, however other compounds of MFO system do not react positively on this ester.
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