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ORIGINAL RESEARCH
Metabolic Interactions in Rats Treated with Acetylsalicylic Acid and Trichloroethylene
B. Zielinska-Psuja, J. Orlowski, A. Plewka*, M. Kaminski*, J. Kowalowka-Zawieja, B. Zieba-Proc
Department of Toxicology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
*Department of Histology & Embriology, Silesian School of Medicine, Katowice-Ligota, Poland
*Department of Histology & Embriology, Silesian School of Medicine, Katowice-Ligota, Poland
Pol. J. Environ. Stud. 1999;8(5):319-325
KEYWORDS
acetylsalicylic acidtrichloroethylenetrichloroethanoltrichloroacetic acidcytochrome P450-dependent monooxygenases
ABSTRACT
The influence of acetylsalicylic acid (ASA) on elimination of trichloroacetic acid and trichloroethanol in the urine and liver and kidney of cytochrome P-450-dependent monooxygenase systems in rats exposed to trichloroethylene (TRI) vapours were examined.
The obtained results show that acetylsalicylic acid decreased the elimination of both trichloroethylene metabolites and induced cytochrome P-450 concentration in the liver, whereas slightly inhibited cytochrome b5 and activites of NADPH-cytochrome P-450 reductase and NADH-cytochrome b5 reductase.
After mixed exposures, acetylsalicylic acid elevated cytochrome P-450 concentration and NADPH-cytochrome P-450 reductase activity to values observed in the control group.
The concentration of cytochrome b5 was much lower than after ASA or trichloroethylene alone.
The activity of NADPH-cytochrome P-450 reductase was strongly inhibited by TRI, whereas in ASA presence was elevated, but it was still lower than in control.
Acetylsalicylic acid stimulates cytochrome P-450, however other compounds of MFO system do not react positively on this ester.
CONFLICT OF INTEREST
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
| eISSN: | 2083-5906 |
| ISSN: | 1230-1485 |
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