A Low Dose of Chlorfenvinphos Affects Hepatic Enzymes in Serum and Antioxidant Enzymes in Erythrocytes and Liver of Rats
A. Łukaszewicz-Hussain*, J. Moniuszko-Jakoniuk
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Department of Toxicology, Medical Academy, 15-222 Białystok, ul. Mickiewicza 2c, Poland
Pol. J. Environ. Stud. 2005;14(2):199–202
The aim of this study was to investigate the effect of chlorfenvinphos administered at a single dose of 0.02 LD50 on the activity of serum of liver damage indicatory enzymes, such as
ß-glucoronidase (BGR), acid phosphatase (AcP) and alanine and aspartate aminotransferases (ALT and AST), as well as on the ac-tivities of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and liver. The animals were divided into two groups: the control group, which received oil, and the experimental groups, which received oil solution of chlorfenvinphos at a dose of 0.02 LD50. After 1, 24 and 48 hours of intoxication with chlorfenvinphos the blood samples were collected and livers were quickly removed. This study indicates that acute intoxication with chlorfenvinphos administered at a dose of 0.02 LD50 leads to liver function disturbances, which is a likely result of increased generation of reactive oxygen species.