Genetic predisposition and environmental conditions are mentioned among the factors modifying the synthesis of IgE immunoglobulin. The aim of the study was to analyze chosen factors in children with high total concentration of IgE (>100 IU/ml). The study included 261 children who were divided according to the serum level of IgE into 3 groups: I - IgE 101-1000 IU/ml; II - IgE >1001 IU/ml and III (control group) with IgE 1-100 IU/ml. The mean age was similar in the study group and equaled 8 years (±4.4). The male sex predominated in all groups of patients with IgE >100 IU/ml, whereas the female sex only in the controls. Predominance of the families with a positive family history of an allergic disease, which usually affected mothers (statistically insignificant), was demonstrated in each group. Regardless of IgE concentration, families with more than one child predominated, even in the group of patients with allergic diseases. Similarly, no significant difference was demonstrated in IgE concentrations when comparing the time of breastfeeding or the season of child's birth in the studied children. A significant relationship between the high serum concentration of IgE, atopic status and living in the city was observed (p<0.05). Another correlation on the border of statistical significance was found between exposure to tobacco smoke and high IgE concentration (p=0.087). Though numerous studies have reported the influence of environmental factors on the excessive production of IgE, our study showed only one significant correlation between high total IgE concentration, atopic status and living in the city.