Effect of Low Frequency Electromagnetic Fields on [3H]Glucose Uptake in Rat Tissues
A. Sieroń1, H. Brus1, J. Konecki2, G. Cieślar1, R. Szkilnik3, P. Nowak3, Ł. Noras2, A. Kwieciński3, R. M. Kostrzewa4, R. Brus3
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1Clinic of Internal Diseases, Angiology and Physical Medicine,41-902 Bytom, Medical University of Silesia in Katowice, Poland 2Department of Histology and Embryology, Medical University of Silesia in Katowice, 41-808 Zabrze, Poland 3Department of Pharmacology, Medical University of Silesia in Katowice, ul. Jordana 38, 41-808 Zabrze, Poland 4Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Pol. J. Environ. Stud. 2007;16(2):309–312
The aims of this study were to evaluate the influence of an extremely low-frequency electromagnetic field (ELF-EMF) on [3H]glucose uptake in the peripheral tissues and organs of rats. Rats were exposed to EL F-EM F (frequency-10 Hz, induction -1.8-3.8 mT) one hour daily for 14 consecutive days. Control animals were sham exposed. On the 15th day (24 hours after last exposure) rats were injected with D-[3H]-6-glucose 500µCi/kg IP. Fifteen minutes later animals were sacrificed by decapitation and peripheral tissues were excised and examined for radioactivity (desintegrations per minute, DPM/100 mg wet tissue weight), which expressed [3H]glucose uptake. In most of the examined tissues and organs, such as liver, kidney, heart muscle, cartilage, connective tissue, tendon and skin, [3H]glucose uptake in EL F-EM F-exposed animals was significantly higher as compared to that in the sham control. Exposure to EL F-EM F did not influence [3H]glucose uptake in the thoracic aorta and the skeletal muscle. It is concluded that ELF-EMF impacts tissue glucose uptake by facilitating glucose transport via cell membranes, dependent and probably also independent of its role in increasing insulin action in insulin-dependent tissues.