Protective Influence of Natural Anthocyanins of Aronia Melanocarpa on Selected Parameters of Antioxidative Status in Experimental Intoxication with Sulphide-2-Chloroethyl-3-Chloropropyl
E. Kowalczyk 1*, K. Charyk 1, P.Fijałkowski 1, J. Niedworok 1, J.Błaszczyk 1, J. Kowalski 2
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1 Department of Human Physiology and Biophysics,
2 Department of Internal Medicine and Cardiological Rehabilitation,
Medical University, Pl. Gen. J. Hallera 1, 90-647 Lódź, Poland
Pol. J. Environ. Stud. 2004;13(3):339-341
Sulphide-2-chloroethyl-3-chloropropyl is an alkylating agent. It posssesses mutagenic and carcinogenic properties, participates in oxidative processes and can induce lipid peroxidation.The aim of our investigation was to define antioxidative activity of natural anthocyanins after single experimental intoxication with sulphide-2-chloroethyl-3-chloropropyl in mice. Catalase activity in hemolysate, thiobarbituric acid reacting substances (TBARS) concentration in hemolysate and selected organs were determined. The study confirms increased lipid peroxidation as a result of sulphide-2-chloroethyl-3-chloropropyl intoxication, but natural anthocyanines derived from Aronia Melanocarpa also seem to play a protective role as an antioxidative agent.
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