This paper studied the impact of new industrial activities on ecological security in agricultural and animal husbandry interlaced areas, and provided reference for eco-environmental protection and sustainable development. A pressure-state-response (PSR) assessment model was established in the case of Yanchi County, Ningxia Hui Autonomous Region. The comprehensive weights of the indexes were determined by AHP and entropy weight, and the ecological security status of agricultural and animal husbandry interlaced areas was evaluated. The results show that the index of pressure system fluctuated and decreased, and went through the stage from “Safe” to “Unsafe”; The index of the state system showed a rising trend, from “Extremely unsafe” to “Relatively safe”, which showed the sensitivity characteristic; The response system index had been increasing year by year, and had stabilized at a “Safe” level in 2019;The overall ecosystem security index showed a fairly good development trend, with significant improvement in ecosystem functions in 2019. On the basis of the stable state system, we should ease the pressure index in the ecological security system of Yanchi County, control the scale of tourists, reduce the damage of farming and animal husbandry to the cultivated layer, and stabilize the population.