Chemical Constituents of the Volatile and Nonvolatile, Cytotoxic and Free Radical Scavenging Activities of Medicinal Plant: Ranunculus millefoliatus and Acanthus dioscoridis
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Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq
Department of Pharmacognosy, Faculty of Pharmacy, Tishk International University-Erbil 44001, Kurdistan Region, Iraq
Department of Chemistry, College of Science, University of Sulaimani, Kurdistan Region, Iraq
Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products, Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Submission date: 2020-05-25
Final revision date: 2020-09-22
Acceptance date: 2020-10-08
Online publication date: 2021-01-28
Publication date: 2021-03-08
Corresponding author
Fuad O. Abdullah   

Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq, 44001, Erbil, Iraq
Pol. J. Environ. Stud. 2021;30(3):1981-1989
In this first reported study, the hydrodistilled volatile oils from the fragrant aerial parts (Ranunculus millefoliatus) and leaves (Acanthus dioscoridis) were investigated by GC-MS and GC-FID. In total 78 constituents, 46 and 44 compounds representing 92.5 and 92.57% of the volatile oil were identified from A. dioscoridis and R. millefoliatus respectively. The main volatile constituents of ADL-Oils were caryophyllene oxide (3.1%), E -phytol acetate (3.6%), (E)-β-ionone (3.7%), spathulenol (8.8%), phytol (15.7%), palmitic acid (23.0%). The major compounds of RMA-Oils were palmitic acid (4.89%), (E)-nerolidol (6.89%), α- copaen-11-ol (11.96%), γ-eudesmol (12.84%) and α-eudesmol (35.98%). The RMA-oils and ADL-oils displayed the cytotoxicity with IC50 12.28 and 15.44 μg/ml respectively. The antioxidant showed that the methanolic extract from RMA was stronger than ADL, with IC50 values (54 and 118 μg/ml) respectively. Likewise, the antioxidant activity of RMA-oils was found to be stronger than ADL-oils (43 and 105 μg/ml) respectively, compared with BHT (IC50, 24 μg/ml), as a positive control.
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