Evaluating Breast Cancer Risk under Exposure to Environmental Estrogen-Like Chemicals
Yuanfang He, Xiaoling Wang, Kusheng Wu
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Department of Preventive Medicine, Shantou University Medical College,
Shantou 515041, Guangdong, China
Submission date: 2016-06-08
Final revision date: 2016-07-17
Acceptance date: 2016-07-18
Publication date: 2016-11-24
Pol. J. Environ. Stud. 2016;25(6):2239-2249
Breast cancer is the most prevalent cancer among women in the world, with a notable increasing prevalence in recent decades. Many environmental compounds with estrogenic activity, called environmental estrogens (EEs), which are especially persistent organic pollutants, may play important roles in the occurrence and development of breast cancer and even treatment and prognosis. EE compounds, including bisphenol A, nonylphenol, phthalates, perfluorooctane sulfonate, polybrominated diphenyl ethers, dioxins, and polychlorinated biphenyls, result from industrial manufacturing and exist ubiquitously in the human environment. With the aggravation of environmental pollution, these compounds are residual in all kinds of environmental matrices – especially in industrialized countries. Humans are frequently exposed to them through various pathways, including body contact, inhalation, diet, household products, dust, and cosmetics. They have been detected in many types of human specimens. Their persistence in environmental matrices and humans has aroused global attention because of their effect on public health, especially the occurrence of breast cancer. In this review, we focus on recent research of these seven familiar EEs in industrial pollutants to provide insight into the evidence for risk of breast cancer with exposure to environmental estrogen-like chemicals and to provide clues for prevention and control of breast cancer.
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