Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System
Saman Shahid1, Muhammad Nawaz Chaudhry1, Nasir Mahmood2, Shaharyar Sheikh3
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1College of Earth and Environmental Sciences, University of the Punjab, Lahore, Pakistan
2Department of Allied Health Sciences & Chemical Pathology
and Department of Human Genetics & Molecular Biology,
University of Health Sciences (UHS), Lahore, Pakistan
3Shaikh Zayed Hospital, Federal Postgraduate Medical Institute, Lahore, Pakistan
Submission date: 2015-01-05
Final revision date: 2015-01-30
Acceptance date: 2015-01-31
Publication date: 2015-07-27
Pol. J. Environ. Stud. 2015;24(4):1783-1794
In Pakistan the Siwalik region is exposed to ionizing radiation (IR) from uranium mineralization. The current research describes the impact of long-term low-dose terrestrial ionizing radiation exposure on the hematopoietic indices of the region’s inhabitants. Mean values of the selected complete blood count (CBC) parameters were calculated to examine low or high trend. A t-test was conducted on the mean values of CBC parameters to analyze parameters showing a significant difference between radiation-exposed people and radiation unexposed people. Most disturbed CBC parameters found low were: mean corpuscular hemoglobin (MCH) 52%, mean corpuscular hemoglobin concentration (MCHC) 44%, and platelets (PLT) 28%. The most affected CBC parameter which was found to be high was lymphocyte count (LYM) 28%. Seven CBC parameters, including hemoglobin (HB), white blood cells (WBC), platelets (PLT), hematocrit (HCT), neutrophils (NEUT), MCH, and MCHC, showed a decrease trend in radiation-exposed residents and two CBC parameters, including red blood cells (RBC) and LYM, showed an increased trend. Significant differences were found in the parameters viz., HB, WBC, MCH, MCHC, HCT, and LYM by the t-test between radiation exposed and unexposed individuals. The odds of developing a low MCH were four times higher and the odds of developing a low MCHC were 4.4 times higher for radiation-exposed individuals as compared to radiation unexposed. The persistent low-dose IR exposure resulted in anemia and immune modulation in radiation-exposed residents.
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