Pyrethroid Insecticide Effect on Platelet Biomembranes of Rats
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Department of Hematology, Qilu Hospital of Shandong University, Ji-nan, Shandong - 250012, China
School of Public Health, Jilin University, Changchun, Jilin - 130012, China
Department of Biochemistry, Sri Krishnadevaraya University, Ananthapuramu - 515003, Andhra Pradesh, India
Submission date: 2018-10-11
Final revision date: 2019-01-10
Acceptance date: 2019-01-12
Online publication date: 2019-09-13
Publication date: 2019-12-09
Pol. J. Environ. Stud. 2020;29(1):703-711
The effect of Tetramethrin- and prallethrin-based mosquito repellent pyrethroids on rat platelet membranes of cholesterol, phospholipids, lipid peroxidation in platelet membrane was investigated. Rats were chronically exposed to these compounds by continuous inhalation for 8-10 hours a day for 2-3 months, which entered into circulation and counted changes in membranes of platelets. Platelet membrane fluidity was determined by DPH. Pyrene fluorescence anisotropy experiments revealed that tetramethrin and prallethrin exposure to subjects, compared with controls, induced a significant decrease in platelet membrane fluidity as measured by DPH and pyrene. A significant increase in lipid peroxidation was observed in the subjects exposed to both compounds. A significant decrease in the activitiesof platelet membrane-bound enzymes, viz., total ATPase, Na+/K+-ATPase and Ca2+-dependent ATPase and Mg2+-ATPase was also recorded.
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