20 surface sediments recovered from the Ergene River have been analyzed in order to assess the extent of anthropogenic inputs into the river. The results of enrichment factor (EF), contamination factor (CF), and pollution load index (PLI) reveal that the sediments of the Ergene River were not polluted with Cu, Fe, Mn, and Ni, but were moderately polluted with As, Cr, Pb, V, and Zn. The highest CF and PLI of As, Cr, and V were observed near the industrial district of Çorlu. These CF and PLI values indicated anthropogenic influence caused by the input of untreated industrial wastewater and domestic sewage.