Cytotoxicity and Antimicrobial Activity of Pivalic and Benzoic Acid-Complexed Cu and Mn Complexes
Bashrat Ali1, Sadia Tahir1, M. Nadeem Akhtar1, Muhammad Yameen2, Rizwan Ashraf1, Tariq Hussain3, Abdul Ghaffar2, Mazhar Abbas3, Tanveer H. Bokhari5, Munawar Iqbal2
More details
Hide details
1Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan
2Department of Applied Chemistry and Biochemistry, GC University, Faisalabad, Pakistan
3Jhang-Campus, University of Veterinary & Animal Sciences Lahore, Pakistan
4Department of Chemistry, The University of Lahore, Lahore, Pakistan
5Department of Chemistry, GC University, Faisalabad, Pakistan
Submission date: 2016-10-06
Final revision date: 2017-01-13
Acceptance date: 2017-01-16
Online publication date: 2017-10-13
Publication date: 2017-11-07
Pol. J. Environ. Stud. 2017;26(6):2861–2867
The complexes of Cu and Mn metals with carboxylates (pivalic acid and benzoic acid) and imidazole were prepared and characterized. The synthesized complexes were screened for antimicrobial activity and cytotoxicity. The FTIR technique was used for characterization. The antibacterial assay revealed that the ligand and complexes are active against Escherichia coli, Staphylococcus aureus and Pasteurella multocida bacterial strains. The haemolytic assay revealed that [Cu(imi)(N3)] and [MnIII(piv)(imi)(N3)] were nontoxic, whereas [Cu(piv)(imi)] and [MnIII(Benz)(imi)(OCH3)] showed moderate toxicity, and [Mn(Him)(N3)2] was highly toxic against human red blood cells (RBCs). Results revealed that Cu and Mn complexes with carboxylates (pivalic acid and benzoic acid) have antimicrobial activities. However, haemlytic assay revealed that the metal complex cytotoxicity was variable and biological activity evaluatuion of newly synthesized metals complexes is suggested for safe applications.