Effect of Long-Term Cadmium Intoxication on Selected Biochemical Parameters in Experimental Animals
E. Kowalczyk, A. Jankowski, J. Niedworok, J. Śmigielski, P. Tyślerowicz
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Department of Pharmacology, Institute of Basic Sciences at Military Medical University in Łódź
Plac Hallera 1, 90-647 Łódź, Poland
Pol. J. Environ. Stud. 2002;11(5):599–601
Cadmium (Cd) is a dangerous occupational and environmental toxin. Exceeding its permissible weekly uptake in meals is a disturbing phenomenon. The aim of this study is to assess the effect of long-term uptake of cadmium chloride on selected biochemical parameters and oxidative stress biomarkers in animal models. Long-term intoxication with cadmium chloride elevated blood serum concentration of urea, creatinine, glucose, AspAT and AlAT activity as well as TBARS and protein carbonyl group concentrations; TBARS concentration in erythrocytes was also elevated as well as 8-hydroxy-2’-deoxyguanosine excretion with urine.