LETTERS TO EDITORS
Effect of Long-Term Cadmium Intoxication
on Selected Biochemical Parameters
in Experimental Animals
E. Kowalczyk, A. Jankowski, J. Niedworok, J. Śmigielski, P. Tyślerowicz
Department of Pharmacology, Institute of Basic Sciences at Military Medical University in Łódź
Plac Hallera 1, 90-647 Łódź, Poland
Plac Hallera 1, 90-647 Łódź, Poland
Pol. J. Environ. Stud. 2002;11(5):599-601
KEYWORDS
ABSTRACT
Cadmium (Cd) is a dangerous occupational and environmental toxin. Exceeding its permissible weekly
uptake in meals is a disturbing phenomenon. The aim of this study is to assess the effect of long-term uptake
of cadmium chloride on selected biochemical parameters and oxidative stress biomarkers in animal models.
Long-term intoxication with cadmium chloride elevated blood serum concentration of urea, creatinine,
glucose, AspAT and AlAT activity as well as TBARS and protein carbonyl group concentrations; TBARS
concentration in erythrocytes was also elevated as well as 8-hydroxy-2’-deoxyguanosine excretion with urine.
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| eISSN: | 2083-5906 |
| ISSN: | 1230-1485 |
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