ORIGINAL RESEARCH
Effect of Nickel (II) Chloride Oral Exposure on Urinary Nickel Excretion and Some Other Elements
K. Janicka, M. Cempel*
 
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Institute of Maritime and Tropical Medicine, Department of Toxicology,
81-519 Gdynia, Powstania Styczniowego 9b, Poland
 
Pol. J. Environ. Stud. 2003;12(5):563–566
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ABSTRACT
Male Wistar rats were given nickel (II) chloride (NiCl2 · 6 H2O) with drinking water (300 or 1200 ppm Ni for 90 days). Urine volume and nickel, zinc, copper, calcium and inorganic phosphorus were measured in 24 h urine after 45 and 90 days of exposure. The results demonstrate that relatively low–level oral ex-posure (300 ppm Ni) induces an increase of urinary Ni excretion (p < 0.001), but no significant changes in other elements. The higher Ni dose (1200 ppm) caused elevation of this metal in urine (p < 0.001), as well as significant changes of urinary volume, and zinc, copper and inorganic phosphorus concentration.
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