Effects of Pre- and Postnatal Zinc Exposure on Adult Rat Brain Dopamine Activity and Behavior
P. Nowak, G. Bielaczyc, R. Szkilnik, L. Labus, J. Dabrowska, A. Bortel,
G. Szczerbak, M. Swoboda, A. Kwiecinski, R. Brus
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Department of Pharmacology, Medical University of Silesia, ul. Jordana 38, 41-808 Zabrze, Poland
Pol. J. Environ. Stud. 2006;15(4):565-572
Pregnant Wistar rats received 50 ppm of zinc (ZnSO4 · 7H2O) in their drinking water for the entire duration of pregnancy. On the day of delivery zinc was removed from the drinking water. Another group, dams, received 50 ppm of zinc in drinking water during the suckling period (from delivery until the 21st day of postnatal life). Their offspring were weaned on the 21st day, at which time zinc was removed from the drinking water. The control group drank tap water only. In 8-12-week-old offspring of all three groups the DA, DOPAC, HVA, 3-MT, 5-HT, 5-HIAA, NA, and MOPEG synthesis rate in the brain was estimated by HPLC/ED technique. Independent behavioral exam were performed such as locomotor and exploratory activity, irritability, yawning and oral activity, stereotype behavior, catalepsy and others. For the above, central DA receptor agonists (quinpirole, SKF 38393, apomorphine, 7-OH-DPAT) or antagonists (haloperidol, SCH 23390) were used. It was found that exposure to zinc during early stages of ontogenic development produce changes in the central dopaminergic system activity of adult offspring. From the above we concluded that uncontrolled supplementation with zinc during pregnancy or lactation can induce disturbance of the central dopaminergic system in adult mammal.
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