Both NOx and O₃ are irritants and harmful pollutants for human health, and it is very reasonable and important to evaluate their effects by combining public perceptions. Five groups of pollutant concentrations and scores (98 healthy people) were available at the same site. Using the optimal Weber constant and Weber-Fischna-Law (W-F-L) change, the results showed that O₃ and NOx were the main irritants compared with other factors in our experiment, and most assessments were approximately in agreement with the pollution level and people’s perception rules. In addition, due to the lack of calculation unity and the essential concept for the present Weber constant, the true value based on real human perceptions was first obtained based on the findings that the exact match between concentrations and score means was the unique breakthrough.