Agarwood is mainly used to make incense, perfume, traditional Chinese medicine, and other products. In some parts of China, some consumers use cigarettes that contain agarwood. Not all Aquilaria trees can generate agarwood; only trees that are damaged by natural and artificial means form resin. Due to the short time of forming resin, there are some differences in the quality of agarwood. This paper studies the effects of the application of cultivated agarwood in incense, cigarettes, and essential oil. First, the differences in combustion as an incense of this cultivated agarwood and three samples of natural agarwood were researched, and the cytotoxic and genotoxic of aerosols of combustion were tested. Subsequently, the effect of the application of this cultivated agarwood in cigarettes was studied. The particulate matter particles of four samples of agarwood incense burning smoke were detected. The ultrafine particles and fine particles accounted for the vast majority (more than 99%) by number and by mass, and these can enter the human alveoli and have a negative impact on health.