By simulating the multipoint seismic ground motions varied with time and space, which transforms into a multi-point seismic load, and introducing calculation of water pressure, the multi-point seismic stability analysis method considering leachate is derived. A method of solving safety factor and deviation analysis is proposed and the calculation program is compiled, with which the sensitivity of the influencing factors is analyzed. The results show that the safety factor when considering the leachate, which declines linearly as the leachate level increases, is smaller than that without consideration; the safety factor shows a linear decreasing trend as the specific weight γ_sw increases, which is more obvious as γ_sw increases. The effect of δ_p, the friction angle of the interface between the landfill and the bottom liner, on the safety factor is obviously larger than that of the cohesion c_p; whatever the leachate level is, as a_max, the maximum acceleration of seismic ground motions increases, and the safety factor shows a declining trend. The calculation of stability analysis considering leachate level influences the safety factor of the landfill, which has important significance for the evaluation of stability and safety of the landfill in wet and rainy areas.