Atrazine-Induced Toxicity and Biochemical Changes in Mus musculus: the Ameliorative Efficacy of Nigella sativa L. (Ranunculaceae) Oil
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Department of Zoology, University of Sargodha, Sargodha 40100, Pakistan
Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan
Department of Plant Science, Quaid-i-Azam University, 45320, Islamabad, Pakistan
Department of Botany, Islamia College Peshawar, 25120, Pakistan
Department of Crop and Animal Production, Sason Vocational School, Batman University, Batman 72060, Turkey
Department of Botany, University of Malakand, Chakdara, Lower Dir, Khyber Pakhtunkhwa 18800, Pakistan
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Department of Biochemistry, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia
Department of Horticulture, Agricultural Faculty, Ataturk University, Erzurum 25240, Turkiye
HGF Agro, Ata Teknokent, TR-25240 Erzurum, Turkiye
University of Chinese Academy of Sciences, (UCAS), Beijing 100049, China
Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11A, Datun Road, Chaoyang District, Beijing 100101, China
Submission date: 2023-12-07
Final revision date: 2024-01-06
Acceptance date: 2024-01-24
Online publication date: 2024-05-09
Publication date: 2024-06-27
Corresponding author
Sajida Batool   

Department of Zoology, University of Sargodha, Sargodha 40100, Pakistan
Muhammad Nauman Khan   

Department of Botany, Islamia College Peshawar, 25120, Pakistan, Pakistan
Pol. J. Environ. Stud. 2024;33(5):5211-5220
The study aimed to evaluate the ameliorative potential of Nigella sativa oil (N.s) against the adverse effects induced by atrazine (ATZ) in mice. Four groups were divided into: Control group (untreated); N.s group (N. sativa oil, 2 mL/kg/BW); ATZ group (atrazine 200 mg/kg/BW); ATZ+N.s group (atrazine 200 mL/kg/BW; and N. sativa oil, 2 mL/kg/BW). All doses were administered by gavage once daily for 4 weeks. The atrazine-administered group showed a significant increase in total leukocytes, granulocytes, and agranulocytes and a decrease in red blood cells, hemoglobin, mean corpuscular volume, and packed cell volume. Serum concentrations of aspartate aminotransferase, alanine transaminase, and alkaline phosphatase were high in the ATZ group. Atrazine exposure reduced serum albumin and total protein levels in the blood. A significantly higher concentration of bilirubin, urea, and creatinine was also found in the ATZ group. The simultaneous administration of atrazine and N. sativa led to improvements in all the parameters studied above. Thus, this study revealed that atrazine exposure has toxic effects on hematological parameters, liver, and kidney function, and that N. sativa oil reduces these toxic effects of atrazine in male mice.
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