Suspended particles of less than 10 μm (PM₁₀) are one of the most important pollutants that create irretrievable damage to human health and the environment. This study surveyed the death rate associated with cardiovascular and respiratory diseases related to PM₁₀. Three sampling stations were selected from various parts of Shiraz, Iran (Southwest of Iran). The concentration of PM₁₀ particles was measured using a Grimm machine. The values of temperature and pressure were also obtained from the Metrological Organization of Shiraz. The data were initially processed in Excel, including pressure and temperature correction, programming, processing (calculating averages), and filtering. The input was entered into AirQ+ and Air Quality Health Impact Assessment model. This model consists of four input parameters (Parameter, Location, AQ data, Supplier) and produces two outputs in the format of tables and graphs. The results presented that the highest share of health impacts attribute to pollutants of air in Shiraz is due to PM₁₀ pollution. The harmful health effects of PM₁₀ significantly increases at concentrations exceeding 40 μg/m³. The model revealed that the death number of respiratory and cardiovascular diseases attributed to the PM₁₀ in Shiraz in 2019 was 92 and 22 respectively, which accounts for 2.4% of the total deaths in Shiraz. It should be concluded that the lack of management for particulate matter pollution can bring about more deaths and cause other health effects.