Frequent use of phosphine over decades for the control of cigarette beetles (Lasioderma serricorne), has led to serious negative effects, including strong insecticide resistance, disruption of biological control by natural enemies, and environmental and human health concerns. As an environmentally friendly alternative to synthetic pesticides, plant-derived pesticides have been the focus of modern research. In this research, the toxicity and repellency effect of plant species extracts of Adhatoda vasica Nees, Azadirachta indica, Nigella sativa, Parthenium hysterophorus, and Thuja orientalis against the adult of L. serricorne were investigated. There were six concentrations 250 mg/L, 500 mg/L, 750 mg/L, 1000 mg/L, 1250 mg/L and 1500 mg/L of each plants species extracts. Both contact and residual toxicity were checked for 24, 48, 72, and 96 h. The experiment was replicated four times using Completely Randomized Design and a Probit analysis was done to determine the LC₅₀ and LC₉₀. The phytochemical profile showed the presence of phytosterols, saponins, di-terpenes, flavonoids, and alkaloids. In both contact and residual toxicity test, the highest level of toxicity was exhibited by A. indica with the lowest LC₅₀ (0.46 mg/L, 1.15 mg/L) and LC₉₀ value of (7.62 mg/L, 8.05 mg/L) followed by A. vasica having LC₅₀ (0.92 mg/L, 0.95 mg/L) and LC₉₀ value of (6.58 mg/L, 8.70 mg/L) respectively. A. indica and A. vasica also showed 100% repellency effect against L. serricorne after 96 h exposure period. The findings of the present study suggested the inclusion of A. indica and A. vasica extracts in the manufacture of novel biopesticides for mitigating L. serricorne.