The study was conducted in a major industrial city in Pakistan (Faisalabad) with a population of 3.2 million. Air quality data was monitored for a whole year using United States Environmental Protection Agency certified instruments, while the World Health Organization (WHO) recommended AirQ+ model was used to assess the human health risks of air pollutants. The annual mean concentration of NO₂ (13.6 μg/m³) was within the permissible limits of Punjab Environmental Quality Standards (PEQS) (40 μg/m³), but the annual mean concentration of PM_2.5 was above both standard limits (106.1 μg/m³). As per the model, contribution of PM₁₀ and PM_2.5 to newborn mortality was 39.7% and 43.9%. Precisely, Acute Lower Respiratory Infections (ALRI) in children under 5 years of age group was significantly high due to PM_2.5 i.e., 44.6%. Overall, PM_2.5 was found to be significantly affecting the mortality rates, including causing a high number of deaths due to natural causes, ALRI in children under 5, Chronic Obstructive Pulmonary Disease (COPD) in those aged 30 or older, and stroke. Based on the findings of the study, it is strongly recommended that comprehensive measures and interventions be implemented to effectively reduce the elevated levels of PM_2.5 in Faisalabad to mitigate the adverse health effects, particularly the increased mortality rates and respiratory illnesses observed in vulnerable populations such as children under 5 and individuals aged 30 or older.