A Study of the Toxic Effects of Six Dibenzofuranes in Mitochondria from Rat Liver
S. Manente1, A. Iero1, R.Fabris1, G.Perin1, V.Rizzoli2 and M. Bragadin1
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1Dipartimento di Scienze Ambientali Univ. Venezia DD2137 30123 Venezia Italy
2Dipartimento di Chimica Biologica, Universita di Padova, Viale G. Colombo 3 35121 Padova Italy
Pol. J. Environ. Stud. 1999;8(3):165–168
The interactions of five dibenzofurans with the mitochondria from rat liver have been investigated. Results indicate at low doses all dibenzofurans induce inhibition of ATP synthesis. The efficiency of ATP synthesis is measured from the ratio (R) between the ADP-stimulated respiratory rate (State 3) and basal respiration (State 4). When R=1, no ATP synthesis occurs. A comparison between the R values for all investigated dibenzofurans (PCDF) shows that the R values are in the same order of magnitude.