Effect of Long-Term T Aluminium Chloride Intoxication on Selected Biochemical Parameters and Oxidative- -Antioxidative Balance in Experimental Animals
E. Kowalczyk*, A. Kopff1 Kopff , J. Kędziora1, J. Błaszczyk, M. Kopff1 , Kopff , J. Niedworok, P. Fijałkowski
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Department of Human Physiology and Biophysics, Medical University of Łódź, Pl. Hallera 1, 90-647 Łódź, Poland
1 Department of Biochemistry, Medical University of Łódź
Pol. J. Environ. Stud. 2004;13(1):41-43
Aluminium is numbered among trace elements with a moderate toxic effect on living organisms. We have attempted to assess the influence of long-term aluminium chloride intake on the biochemical parameters and oxidative stress biomarkers in experimental animals. Three months’ administration of aluminium chloride in drinking water at a dose of 80 mg/l significantly elevated blood serum urea and creatinine concentration, as well as oxidative stress biomarkers such as: TBARS content in erythrocytes hemolysate, protein carbonyl groups concentration and 8-hydroxy-2’-deoxyguanosine excretion with urine.
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