Interactive Effects of BDE-153 and its Metabolite 2,4-DBP on Biochemical Status in Crucian Carp (Carassius auratus)
Guanghua Lu1,2, Jianchao Liu2, Fuhai Zhang3, Matthew Nkoom2, Donghai Wu2
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1College of Hydraulic and Civil Engineering, XiZang Agricultural and Animal Husbandry College, Linzhi, China
2Key Laboratory of Integrated Regulation and Resources Development, College of the Environment,
Hohai University, Nanjing 210098, China
3Anhui Environmental Monitoring Center, Hefei 230061, China
Submission date: 2017-07-05
Final revision date: 2017-08-05
Acceptance date: 2017-08-06
Online publication date: 2018-02-06
Publication date: 2018-03-12
Pol. J. Environ. Stud. 2018;27(3):1155–1163
Polybrominated diphenyl ethers (PBDEs), which belong to the class of brominated flame-retardants, are widely used in industrial products. PBDEs have been detected in varied environmental matrices and they can induce various toxicities such as neurotoxicity, cytotoxicity, and endocrine-disrupting effects in animals. The main objective of this study was to investigate the effects of 2,2’,4,4’,5,5’-hexabromodiphenyl ether (BDE-153), 2,4-dibromophenol (2,4-DBP), and their mixtures on the endocrine system, including acetylcholinesterase (AChE) of brain, ethoxyresorufin-O-deethylase (EROD), glutathione-S-transferase (GST), and superoxide dismutase (SOD) of liver in crucian carp (Carassius auratus). Fish were exposed to BDE-153 (0.2-100 mg/kg in food), 2,4-DBP (0.2-100 mg/kg in food), and their mixture for seven days. BDE-153 alone or in combination with 2,4-DBP significantly reduced brain AChE activity and increased liver EROD activity while no significant effects were observed for 2,4-DBP alone. The simultaneously elevated GST and SOD activities were found at higher doses of BDE-153 and 2,4-DBP (alone and in combination), and exhibited obvious positive correlation (0.76<R<0.89). With regards to the induction fold of biomarker responses, 2,4-DBP has a lower toxicity than its parent compound BDE-153. However, the joint effects of BDE-153 and 2,4-DBP were not enhanced with regard to the four enzymatic activities.