ORIGINAL RESEARCH
Neurotoxic Effect of Copper Salts in Rats
A. Plech, T. Klimkiewicz, H. Jakrzewska
Department of Pharmacology, Medical Faculty in Zabrze of the Silesian, Medical University, H. Jordan 38, 41-808 Zabrze, Poland
Pol. J. Environ. Stud. 2000;9(4):301–304
KEYWORDS
ABSTRACT
Neurotoxic effects of copper ions after intraperitoneal (ip) and intracere-broventricular (icv) injections of CuSO4·5H2O and Cu(CH3COO)2· H2O at the range of doses 1-100 nmols icv and 0,1-100 mmols/kg ip was determined in rats using two behavioural methods: exploratory and locomotor activity in an open field test and spatial memory in a water maze test. It has been found that higher doses of copper salts (100nmols icv and 100 mmols/kg ip) significantly de-creased spatial memory of rats.
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