ORIGINAL RESEARCH
Neurotoxic Effect of Copper Salts in Rats
A. Plech, T. Klimkiewicz, H. Jakrzewska
 
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Department of Pharmacology, Medical Faculty in Zabrze of the Silesian, Medical University, H. Jordan 38, 41-808 Zabrze, Poland
 
Pol. J. Environ. Stud. 2000;9(4):301–304
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ABSTRACT
Neurotoxic effects of copper ions after intraperitoneal (ip) and intracere-broventricular (icv) injections of CuSO4·5H2O and Cu(CH3COO)2· H2O at the range of doses 1-100 nmols icv and 0,1-100 mmols/kg ip was determined in rats using two behavioural methods: exploratory and locomotor activity in an open field test and spatial memory in a water maze test. It has been found that higher doses of copper salts (100nmols icv and 100 mmols/kg ip) significantly de-creased spatial memory of rats.
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