The Way Kuripan River is an important water resource in Bandar Lampung City. However, its quality deteriorates continuously due to land use change accompanied by housing expansion and open areas. This study aims at analyzing its water quality and pollution level based on the present land-use zoning. Three zones are determined based on the dominant land use covering the riverbank sides. Water sampling was carried out at nine settling points (3 samples per zone) to measure the level of BOD5, COD, TSS, Escherichia coli contends, and also Pollution Index (PI), as well as the Biodegradable Index (BI). The results showed that the water has been experiencing pollution for grade-C river overall data. However, based on the zoning, all of the parameters of the upstream sides are below quality standard (QS), while at the middle stream, the BOD₅ has exceeded QS (21.9-26.4 mg/L), whereas at the downstream, the parameters of BOD₅, COD, and Escherichia coli have exceeded from the QS. The PI and BI values indicated moderately polluted downstream, with the average biodegradable. For this reason, paying attention to land use change is important to assess the level of river pollution. The study results also found that organic matter from domestic is the primary pollutant of the river. Therefore controlling the upstream in accordance with regional spatial planning regulations and followed by a conservation movement as well as change people’s behavior to be more caring about environmental management for catchment areas are the urgent actions for restoring and improving the river water quality.