Phytoremediation of Cd, As, Cu, and Zn by Spirulina Platensis is one of the most cost-effective approaches and environmental friendly technologies used to remediate contaminants from contaminated water. The removal rates of Cd, As, Cu, and Zn in the field experiment were 14.95, 9.45, 35.55, and 73.95 μg/g/d, respectively. The highest concentrations of these metals accumulated in S. Platensis after 90 d of the laboratory/field collected samples were 58.9/98.68, 29.86/47.98, 43.28/235.86, and 249.67/390.65 μg/g dry wt., respectively, over the experiment. Only 55% Cd, 35% As, 85% Cu, and 95% of Zn removed from the water were used by S. Platensis. The bioconcentration factors were recorded for the metals in field/laboratory: for Cd (BCF=90/536), As (BCF=135/2,155), Cu (BCF=34,200/62,300) and Zn (BCF=32,500/95,300). The data obtained suggest that cyanobacterium S. Platensis has promising potential and can be used in a synergistic way to remediate wastewater polluted by Cd, As, Cu, and Zn.