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ORIGINAL RESEARCH
Concentration of Porphyrins in Rat Liver and Kidneys after Repeated Administration of Hexabromobenzene and Tetrabromobisphenol-A
B. Frydrych, J. A. Szymanska, A. Swiderska-Comer
Department of Toxicology, Faculty of Pharmacy Medical University of Łódź, Łódź, Poland
Pol. J. Environ. Stud. 2006;15(4):543-548
KEYWORDS
ABSTRACT
The aim of this study was to complete research on the porphyrogenic effect of hexabrombenzene (HBB) and tetrabromobisphenol-A (TBBP-A).
Experiments were performed on female Wistar rats. The examined compounds were administered in sunflower oil intragastrically in 3 doses. The determination of porphyrins in tissues was carried out by means of high-performance liquid chromatography.
Repeated HBB administration caused a 3-8 times increase of total concentration of high carboxylated porphyrins (octa- and heptacarboxyporphyrins). The concentrations of these porphyrins were significantly lower in the liver of rats exposed to TBBP-A. however, in the kidneys significant alterations in porphyrins concentrations concerned only HBB.
Experiments were performed on female Wistar rats. The examined compounds were administered in sunflower oil intragastrically in 3 doses. The determination of porphyrins in tissues was carried out by means of high-performance liquid chromatography.
Repeated HBB administration caused a 3-8 times increase of total concentration of high carboxylated porphyrins (octa- and heptacarboxyporphyrins). The concentrations of these porphyrins were significantly lower in the liver of rats exposed to TBBP-A. however, in the kidneys significant alterations in porphyrins concentrations concerned only HBB.
CONFLICT OF INTEREST
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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| eISSN: | 2083-5906 |
| ISSN: | 1230-1485 |
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