The distribution characteristics of heavy metal content in the soil of Guizhou real estate hook vine under different land use methods were explored, and the basic data for the high-quality and efficient cultivation of URM producing areas in Guizhou real estate was explored. Taking the soil of the hook vine production area as the research object, the contents of six heavy metals (Cu, As, Cd, Hg, Pb and Cr) in the root zone and non-root zone of the hook vine production area under different land use patterns were studied, and the pollution characteristics of heavy metals were evaluated by single factor and Nemerow composite index. The results showed that contents of heavy metals in URM producing areas in Guizhou are different under different forms of land use. The contents of Cu, As, Hg, Pb and Cr are invariably the highest in URM bases. It is found from the grading of soil heavy metal contents in URM producing areas, contents of all other heavy metals except Cd in forest land are compliant with standards. Under different forms of land use, only forest land is contaminated by heavy metal Cd. A certain antagonistic or synergistic action exhibits among different heavy metals. In general, soil heavy metal contents in URM producing areas in Guizhou are relatively low. Specifically, heavy metal contents in URM bases are significantly higher than those in forest land and waste land, which is mainly attributed to massive fertilization. Therefore, fertilization should be reduced in the practical production process.