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eISSN: 2083-5906
ISSN: 1230-1485
ISSN: 1230-1485
ORIGINAL RESEARCH
Effect of Some Lysosomotropic Substances on Erythrocyte Membrane
1
Department of Physics and Biophysics, Agricultural University, Norwida 25, 50-375 Wrocław, Poland
2
Department of Chemistry, Technical University of Wrocław, Wrocław, Poland
Pol. J. Environ. Stud. 1997;6(6):21-24
KEYWORDS
ABSTRACT
The effect of N,N- dimethylaminoethyl esters of fatty acids (DM-n) on pig red blood cell hemolysis and erythrocyte membrane fluidity has been investigated. In the hemolytic experiments, the hemolytic activity of the compounds studied was determined and was found to increase with alkyl chain length and following the sequence: DM-15 > DM-13 > DM-11 > DMDA > DM-9. The fluorometric studies were conducted using the fluorescent probe TMA-DPH, which allowed us to calculate the polarization coefficient P and hence determine relative changes in membrane fluidity induced by the lysosomotropic substances. The compounds with the highest hemolytic activity, which have fifteen- and thirteen-carbon-atom alkyl chains (DM-15 and DM-13), significantly affect the erythrocyte membrane fluidity.
CONFLICT OF INTEREST
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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| eISSN: | 2083-5906 |
| ISSN: | 1230-1485 |
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