This work analyzes the influence of air-ions of different types and concentrations on people subjected to physical effort and at rest. The outcome of the conducted research indicates that air-ions at a concentration level of 7.5 million ions/cm³ decrease the consumption of O₂ by around 20%, and release CO₂. Furthermore, the positive air-ions shorten the period necessary to achieve the anaerobic change threshold by almost 70%, at a high significance ratio of 0.001. A secondary research outcome also shows that the change of these physiological indicators probably results from the permeation of ionized molecules to the lower parts of human lungs.