In order to revealed the spatial-temporal correlation characteristics and interaction relationship of multifunctional land use in the county of Jiangsu Province, which could provide theoretical support for the spatial planning of the county. This paper constructed multiple functional identification system from three dimensions of production-living-ecological, and quantitatively measures 55 counties’ spatial equilibrium state and space-time effect of “production-living-ecological” function in 1996, 2005 and 2015 by means of coupling coordination degree model, Theil coefficient and its decomposition, and LISA time path analysis. The results showed that spatial equilibrium level of multifunctional land use function in the county of Jiangsu Province was relatively low from 1996 to 2015, presenting the spatial characteristics of the overall dispersion and local agglomeration. The coordination degree of multifunctional land use had spatial differentiation characteristics,which were closely related to the stage of social economic development. The time-space transition of multiple functional coordination degree was generally consistent with the cold-hot spot pattern. The regions with relatively long LISA time path were scattered in southern Jiangsu (Nanjing, Suzhou, Wuxi, Changzhou and Yangzhou). The regions with relatively short LISA time path were scattered in northern Jiangsu, central Jiangsu. The multiple functional coordination degree was relatively low in these areas.The county with the largest LISA time path curvature were Zhenjiang, Xinghua, Yancheng, Guanyun etc. Nevertheless, the curvature of LISA time path in most parts of central Jiangsu and northern Jiangsu was generally small. It can be seen that the path locking effect of development of multifunctional land use coordination degree was strong.