Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant Escherichia coli and Pseudomonas aeruginosa
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College of Life Sciences, North China University of Science and Technology, 21 Bo Hai Road, Tangshan, P. R. China
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China
General Medicine Department, Fauji Foundation Hospital (FFH), Rawalpindi Pakistan
Department of Biological Sciences, International Islamic University Islamabad Pakistan
Institute of Biochemistry, University of Balochistan, Quetta 87300, Pakistan
Department of Biosciences, COMSATS University 45500, Islamabad Pakistan
National Institute for Genomics and Advanced Biotechnology (NIGAB), National Agriculture Research Centre, Islamabad
Institute of Biotechnology and Genetic Engineering (IBGE), The University of Agriculture Peshawar, 25130, Pakistan
Department of Botany, Islamia College Peshawar, 25120, Pakistan
Biology Laboratory, University Public School, University of Peshawar, 25120 Peshawar, Pakistan
Department of Plant Sciences, Quaid-i-Azam University Islamabad 45320, Pakistan
Batman University, Department of Crop and Animal Production, Sason Vocational School, Batman, 72060, Turkey
Department of Botany and Microbiology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia
Botany Department, Faculty of science, Mansoura University, Mansoura 35511, Egypt
Submission date: 2023-08-20
Final revision date: 2023-10-31
Acceptance date: 2023-11-30
Online publication date: 2024-04-30
Publication date: 2024-06-07
Corresponding author
Imdad Kaleem   

Department of Biosciences, COMSATS University 45500, Islamabad Pakistan
Muhammad Nauman Khan   

Department of Botany, Bacha Khan University, Charsadda, KP, Pakistan
Pol. J. Environ. Stud. 2024;33(4):4893-4902
Nanotechnology offers exciting prospects against infectious agents, particularly multidrug resistance bacteria (MDR), which is the roaring concern of this era. Zinc oxide nanoparticles (ZnO-Nps) efficiently deliver therapeutic agents into living systems due to their biocompatibility and bioactivity, which make them highly effective against infectious pathogens. The present investigation was designed to investigate the impact of the ZnO-Nps in combination with the Piperacillin-Tazobactam (TZP) drug against MDR. TZP are beta-lactam antibiotics highly effective against Gram-positive and Gram-negative bacteria such as Pseudomonas aeruginosa, and are recommended for the empirical treatment of Febrile neutropenia (FN) associated with chemotherapy treatment. For this study, three different-sized ZnONp combinations were used. The extended-spectrum beta-lactamase (ESBLs) producing Escheria coli and MDR P. aeruginosa strain sensitivity profiling towards different combinations of ZnO-Nps and Piperacillin-Tazobactam were measured. The synthesized Zno-Nps w ere d esignated a s Z n-1, Z n- 2, and Zn-3 based on their sizes, and were made in different combinations with the commercially available drug TZP (ZnO-Nps+ Drug) against MDR E.coli and P. aeruginosa. There was no synergistic effect observed against growth inhibition of E.coli. The combined dose of Zn-1 and TZP showed better antibacterial efficacy even as compared to the pure drug against P. aeruginosa. The study revealed that the dosage and biological activity of drugs used to treat fatal human diseases like cancer can be decreased while their efficacy can be boosted by using ZnO nanoparticles as powerful drug delivery systems.
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