The population of Serbia’s South Pannonian Basin obtains its drinking water supply from groundwater. High alkalinity; the presence of iron, manganese, and the ammonium ion; low hardness; and high concentrations of organic substances and arsenic are general characteristics of these groundwaters. One of the major drinking water supply issues in the South Pannonia Basin is the high concentration of arsenic, which in some cases exceeds several times the maximum allowable concentration. A health risk assessment model was applied to calculate cumulative exposure to As as well as toxic and carcinogenic risks resulting from drinking raw groundwater contaminated by As in the South Pannonian Basin.