ORIGINAL RESEARCH
Environmental Exposure to Lead Could Enhance Susceptibility to Oxidative Stress in Patients with Pollenosis
A. Dlugosz1, J. Liebhart2, D. Piotrowska1, A. Dor2, E. Liebhart2, H. Gorecka3
1Department of Toxicology, Wrocław Medical University, Traugutta 57/59, 50-417 Wrocław, Poland
2Katedra i Klinika Chorób Wewnętrznych i Alergologii, Wrocław Medical University
3Instytut Technologii Nieorganicznej i Nawozów Mineralnych Politechniki Wrocławskiej
2Katedra i Klinika Chorób Wewnętrznych i Alergologii, Wrocław Medical University
3Instytut Technologii Nieorganicznej i Nawozów Mineralnych Politechniki Wrocławskiej
Pol. J. Environ. Stud. 2006;15(2):229–233
KEYWORDS
environmental pollutionOxidative stresspollen allergymalondialdehyde (MDA)superoxide dismutase (SOD)glutathione peroxidase (GPx)glutathione (GSH)total peroxideslead (Pb)nickel (Ni)
ABSTRACT
The parameters of oxidative stress (MDA, SOD, GPx, H2O2, GSH) and metals concentration were measured on a pollen-allergic sample (64 people) and the correlation between parameters were examined. There were no differences in parameters between pollenotics and control (35 people) except for the level of reduced glutathione which was statistically significant lower at pollenotics. There were no differences in the level of metals in blood or hair. The statistically significant correlation between Pb and SOD (r = 0.74 p = 0.000) at pollenotics suggests that environmental exposure to lead could stimulate the intensity of hay fever symptoms connected with free radicals processes.
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