ORIGINAL RESEARCH
Heptoprotective Role of Artemisia scoparia Waldst. and Kit Against CCl4-induced Toxicity in Rats
Tayyaba Sher Waris1, Muhammad Rashid Khan1, Naseer Ali Shah2, Muhammad Shuaib3, Firasat Hussain4, Muhammad Ishaq5, Zul Kamal5, 6, Umar Zeb7, Sajjad Ali8, Kashif Ali9, Sajjad Ahmed10, Fida Hussain11
 
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1Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
2Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
3School of Ecology and Environmental Science, Yunnan University,
No. 2 North Cuihu Road, Kunming, Yunnan, 650091, P.R. China
4Yunnan institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, P.R. China
5School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, District Minhang Shanghai, China
6Shaheed Benazir Bhutto University, Sheringal, KP, Pakistan
7Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education,
College of Life Science, Northwest University, Xian 710069, P.R. China
8Department of Botany, Bacha Khan University Charsadda, Pakistan
9Department of Botany, Islamia College University Peshawar, Pakistan
10Key Laboratory of Molecular Epigenetics, Ministry of Education, School of Life Sciences,
Northeast Normal University, Changchun, 130024, Jilin, P.R. China
11School of Resources, Environmental and Chemical Engineering Nanchang University,
Nanchang Jiangxi, P.R. China
Online publish date: 2018-02-12
Publish date: 2018-03-12
Submission date: 2017-04-10
Final revision date: 2017-05-18
Acceptance date: 2017-05-24
 
Pol. J. Environ. Stud. 2018;27(3):1307–1314
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ABSTRACT
In this study, the methanol extract of Artemisia scoparia was evaluated for its protective potential against carbon tetrachloride (CCl4)-induced hepatic toxicity. Seven groups of mature albino rats were used in the course of the experiment and each group was treated with specific doses of plant extract and CCl4. Silymarin was used as a standard protective drug. The results of the experiment revealed that Artemisia scoparia plant extract was successful in fighting CCl4 toxicity as it clearly reduced the elevated levels of liver serum markers (alkaline phosphatase and alkaline aminotransferase), lipid peroxidation, nitrite content, and H2O2 on one side while enhancing the levels of antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione-s-transferase, γ-Glutamyltranspeptidase, and glutathione reductase) and protein content. It also protected DNA from the damaging effects of CCl4. The findings of this study demonstrate that Artemisia scoparia plant extract plays a significant role in preventing the hepatic damages instigated with CCl4 and can be used as a protective agent against oxidative stress-associated disorders.
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