This research aims to assess the sustainability and feasibility of the production of Pleurotus ostreatus using ground coffee seed and pulp waste as substrate, and then demonstrating its economic profitability. Different raw materials were characterized as substratum and technical aspect production in the greenhouse for P. ostreatus were analyzed with the economic analysis for financing the project. With this technique, we found an option of sustainable model production, which concedes added value to the agricultural wastes from coffee processing once is used as a source of substrates for the production of Pleurotus ostreatus. The results obtained from the production of mushrooms through the waste from ground coffee and pulp are feasible and profitable in San Salvador. The use of coffee waste in the production of mushrooms will reduce the waste or biomass resulting from the coffee industry, therefore, it is a sustainable alternative in environmental terms. Moreover, economic analyses from PI’s were 3.047052287, given that it was >1, consequently, the project was accepted, while the IRR was 51.47% per year, that is $ 0.52 which is recovered for every dollar invested. Hence, in terms of financial analyses, it is believed that mushroom production is economically profitable and environmentally sustainable.