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ORIGINAL RESEARCH
HPLC Analysis of Amoxicillin Using AccQ-Fluor
Reagent for Pre-Column Derivatization
Dorota Kowalczuk, Anna Galewska
Chair and Department of Medicinal Chemistry, Medical University of Lublin,
Chodźki 6, 20-093 Lublin, Poland
Chodźki 6, 20-093 Lublin, Poland
Pol. J. Environ. Stud. 2012;21(1):139-143
KEYWORDS
ABSTRACT
A simple procedure to perform for the determination of amoxicillin is presented, based on reaction with
1-[(quinolin-6-ylcarbamoyl)oxy]pyrrolidine-2,5-dione (AccQ-Fluor) in borate buffer medium at pH of 7.4.
The resulting amoxicillin+AccQ-Fluor derivative was determined by reversed-phase chromatography with
combined fluorescence (λex=245 nm/λem=368 nm) and UV detection (λ=245 nm) for control. The calibration
graph was linear (r=0.9992 ) over the range 5.0-30 μg/mL. The method was applied to the determination of
amoxicillin in pharmaceutical formulations with acceptable precision and accuracy.
CONFLICT OF INTEREST
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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| eISSN: | 2083-5906 |
| ISSN: | 1230-1485 |
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