About the Journal
In Memory of Professor Jerzy Radecki
Ownership and Management Statement
Editorial Office
Editorial Board
Scope
Impact Factor
Indexed by
Journal Impact Factor contributing items
Publication Frequency
Revenue Sources & Business Model
Contact
Subscription
Current issue
Online first
Instructions for Authors
Copyright & Licensing
Publication Fees
Editorial policies
Publication Policy Overview
Peer Review Policy
Research Ethics and Malpractice Policy
Plagiarism Policy
Conflict of Interest Policy
Open Access Policy
Instructions for Reviewers
Generative AI and AI-Assisted Technologies Policy
Advertising Policy
Direct Marketing & Manuscript Solicitation
Digital Archiving and Preservation Policy
CrossMark, Correction, and Retraction Policy
Archive
Publication Fees
Copyright & Licensing
Editorial policies
Publication Policy Overview
Peer Review Policy
Research Ethics and Malpractice Policy
Plagiarism Policy
Conflict of Interest Policy
Open Access Policy
Instructions for Reviewers
Generative AI and AI-Assisted Technologies Policy
Advertising Policy
Direct Marketing & Manuscript Solicitation
Digital Archiving and Preservation Policy
CrossMark, Correction, and Retraction Policy
eISSN: 2083-5906
ISSN: 1230-1485
ISSN: 1230-1485
REVIEW PAPER
Prunus spinosa L. – Source of Bioactive
Compounds with Antioxidant and Pharmacological
Predicted activity
1
Department of Pharmacology, Faculty of Pharmacy, Ovidius University of Constanta,
900470 Constanta, Romania
2
Department of Cellular and Molecular Biology, Faculty of Pharmacy, Ovidius University of Constanta,
900470 Constanta, Romania
3
Department of Toxicology, Faculty of Pharmacy, Ovidius University of Constanta, 900470 Constanta, Romania
4
Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University,
800010 Galati, Romania
5
Faculty of Natural and Agricultural Sciences, Ovidius University of Constanța, 900470 Constanța, Romania
Submission date: 2025-06-30
Final revision date: 2025-08-12
Acceptance date: 2025-08-23
Online publication date: 2025-12-01
Corresponding author
Verginica Schröder
Department of Cellular and Molecular Biology, Faculty of Pharmacy, Ovidius University of Constanta,, Str. Căpitan Aviator Al. Șerbănescu, nr.6, Campus,, 900470, Constanta, Romania
Department of Cellular and Molecular Biology, Faculty of Pharmacy, Ovidius University of Constanta,, Str. Căpitan Aviator Al. Șerbănescu, nr.6, Campus,, 900470, Constanta, Romania
KEYWORDS
Prunus spinosa LpolyphenolsHPLCantioxidant activityantimicrobial effectDPPHgallic acidFolin-Ciocalteuextractcomparative studies
TOPICS
ABSTRACT
Prunus spinosa L. (blackthorn) is a valuable source of bioactive compounds, including flavonoids,
anthocyanins, phenolic acids, vitamins, and minerals, which confer important antioxidant, antibacterial,
and anti-inflammatory properties. This comparative review synthesizes experimental data from our
previously published research and from the global literature to highlight the phytochemical composition,
variability, and potential application prospects of these fruits. The diversity of results obtained in
terms of total phenolic content (TPC), total anthocyanin content (TAC), and total flavonoid content
(TFC) and biological activities can be explained by the variability of the extraction method, as well
as the geographical origin of Prunus spinosa L., and demonstrates its relevance for health applications.
The results of this comprehensive review revealed an increased potential of Prunus spinosa L. extracts
for phytotherapeutic, nutraceutical, and functional product applications.
CONFLICT OF INTEREST
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
REFERENCES (93)
1.
MARČETIĆ M., SAMARDŽIĆ S., ILIĆ T., BOŽIĆ D.D., VIDOVIĆ B. Phenolic composition, antioxidant, anti-enzymatic, antimicrobial and prebiotic properties of Prunus spinosa L. fruits. Foods. 11 (20), 3289, 2022. https://doi.org/10.3390/foods1....
2.
ALIYAZICIOGLU R., YILDIZ O., SAHIN H., EYUPOGLU O.E., OZKAN M.T., KARAOGLU S.A., KOLAYLI S. Phenolic components and antioxidant activity of Prunus spinosa from Gumushane, Turkey. Chemistry of Natural Compound. 51 (2), 346, 2015. https://doi.org/10.1007/s10600....
3.
NEGREAN O.-R., FARCAS A.C., POP O.L., SOCACI S.A. Blackthorn - A valuable source of phenolic antioxidants with potential health benefits. Molecules. 28 (8), 3456, 2023. https://doi.org/10.3390/molecu....
4.
VIDAKOVIĆ A., BENIĆ L., MRVIČIĆ I., PEŠUT E., JAKŠIĆ V., POLJAK I. Morphological variation in blackthorn (Prunus spinosa L.) populations in the northwestern part of the Balkan Peninsula - absence of geographical and environmental structure. Acta Societatis Botanicorum Poloniae. 93, 1, 2024. https://doi.org/10.5586/asbp/1....
5.
GÜNEŞ F. Medicinal plants used in the Uzunköprü District of Edirne, Turkey. Acta Societatis Botanicorum Poloniae. 86 (4), 2017. https://doi.org/10.5586/asbp.3....
6.
VELICKOVIC J., KOSTIC D., STOJANOVIC G., MITIC S., MITIC M., RANDJELOVIC S., DJORDJEVIC A. Phenolic composition, antioxidant and antimicrobial activity of the extracts from Prunus spinosa L. fruit. Hemijska Industrija. 68 (3), 297, 2014. https://doi.org/10.2298/HEMIND....
7.
NISTOR O.V., MILEA Ș.A., PĂCULARU-BURADA B., ANDRONOIU D.G., RÂPEANU G., STĂNCIUC N. Technologically driven approaches for the integrative use of wild blackthorn (Prunus spinosa L.) fruits in foods and nutraceuticals. Antioxidants. 12 (8), 1637, 2023. https://doi.org/10.3390/antiox....
8.
POPOVIC B.M., BLAGOJEVIĆ B., KUCHARSKA A.Z., AGIĆ D., MAGAZIN N., MILOVIĆ M., SERRA A.T. Exploring fruits from genus Prunus as a source of potential pharmaceutical agents - in vitro and in silico study. Food Chemistry. 358, 129812, 2021. https://doi.org/10.1016/j.food....
9.
KORAQI H., YÜKSEL AYDAR A., PANDISELVAM R., QAZIMI B., KHALID W., TRAJKOVSKA PETKOSKA A., ÇESKO C., RAMNIWAS S., MOHAMMED BASHEERUDDIN ASDAQ S., RUSTAGI S. Optimization of extraction condition to improve blackthorn (Prunus spinosa L.) polyphenols, anthocyanins and antioxidant activity by natural deep eutectic solvent (NADES) using the simplex lattice mixture design method. Microchemical Journal. 200, 110497, 2024. https://doi.org/10.1016/j.micr....
10.
MAGIERA A., CZERWIŃSKA M.E., OWCZAREK A., MARCHELAK A., GRANICA S., OLSZEWSKA M.A. Polyphenol-enriched extracts of Prunus spinosa fruits: anti-inflammatory and antioxidant effects in human immune cells ex vivo in relation to phytochemical profile. Molecules. 27 (5), 1691, 2022. https://doi.org/10.3390/molecu....
11.
STANKOVIĆ M.I., SAVIĆ V. Lj., ŽIVKOVIĆ J.V., TADIĆ V.M., ARSIĆ I.A. Tyrosinase inhibitory and antioxidant activity of wild Prunus spinosa L. fruit extracts as natural source of bioactive compounds. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 47 (3), 2019. https://doi.org/10.15835/nbha4....
12.
POZZO L., RUSSO R., FRASSINETTI S., VIZZARRI F., ÁRVAY J., VORNOLI A., CASAMASSIMA D., PALAZZO M., DELLA CROCE C.M., LONGO V. Wild Italian Prunus spinosa L. fruit exerts in vitro antimicrobial activity and protects against in vitro and in vivo oxidative stress. Foods. 9 (1), 2019. https://doi.org/10.3390/foods9....
13.
VARGA E., DOMOKOS E., FOGARASI E., STEANESU R., FÜLÖP I., CROITORU M.D., LACZKÓ-ZÖLD E. Polyphenolic compounds analysis and antioxidant activity in fruits of Prunus spinosa L. Acta Pharmaceutica Hungarica. 87 (1), 2017.
14.
CAPEK P., KOŠŤÁLOVÁ Z. Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins. Carbohydrate Research. 515, 2022. https://doi.org/10.1016/j.carr....
15.
CAPEK P., UHLIARIKOVÁ I. Antioxidant active polysaccharides extracted with oxalate from wild blackthorn fruits (Prunus spinosa L.). International Journal of Molecular Sciences. 25 (8), 2024. https://doi.org/10.3390/ijms25....
16.
MAGIERA A., CZERWIŃSKA M.E., OWCZAREK A., MARCHELAK A., GRANICA S., OLSZEWSKA M.A. Polyphenols and Maillard reaction products in dried Prunus spinosa fruits: quality aspects and contribution to anti-inflammatory and antioxidant activity in human immune cells ex vivo. Molecules. 27 (10), 2022. https://doi.org/10.3390/molecu....
17.
OLESIŃSKA K., WILCZYŃSKI K., KAŁWA K. The effect method of preservation on selected bioactive compounds and antioxidant activity in blackthorn fruits (Prunus spinosa L.). Agronomy Science. 73 (3), 2018. https://doi.org/10.24326/as.20....
18.
OLESIŃSKA K., SUGIER D., SĘCZYK Ł. The influence of selected preservation methods and storage time on the content of antioxidants in blackthorn (Prunus spinosa L.) fruits. Agronomy Science. 74 (1), 2019. https://doi.org/10.24326/as.20....
19.
GUNES R. A study on quality properties of blackthorn (Prunus spinosa L.) fruit powder obtained by different drying treatments. Bio Web of Conferences. 85, 2024. https://doi.org/10.1051/biocon....
20.
BACKES E., LEICHTWEIS M.G., PEREIRA C., CAROCHO M., BARREIRA J.C.M., KAMAL GENENA A., JOSÉ BARALDI I., FILOMENA BARREIRO M., BARROS L., FERREIRA I.F.C.R. Ficus Carica L. and Prunus spinosa L. extracts as new anthocyanin-based food colorants: a thorough study in confectionery products. Food Chemistry. 333, 2020. https://doi.org/10.1016/j.food....
21.
ELEZ GAROFULIĆ I., ZORIĆ Z., PEDISIĆ S., BRNČIĆ M., DRAGOVIĆ-UZELAC V. UPLC-MS 2 profiling of blackthorn flower polyphenols isolated by ultrasound-assisted extraction. Journal of Food Science. 83 (11), 2018. https://doi.org/10.1111/1750-3....
22.
KAVAZ YUKSEL A. The effects of blackthorn (Prunus spinosa L.) addition on certain quality characteristics of ice cream. Journal of Food Quality. 38 (6), 2015. https://doi.org/10.1111/jfq.12....
23.
MIKULIC-PETKOVSEK M., STAMPAR F., VEBERIC R., SIRCELJ H. Wild Prunus fruit species as a rich source of bioactive compounds. Journal of Food Science. 81 (8), 2016. https://doi.org/10.1111/1750-3....
24.
DRĂGHICI-POPA A.-M., BOSCORNEA A.C., BREZOIU A.-M., TOMAS Ș.T., PÂRVULESCU O.C., STAN R. Effects of extraction process factors on the composition and antioxidant activity of blackthorn (Prunus spinosa L.) fruit extracts. Antioxidants. 12 (10), 2023. https://doi.org/10.3390/antiox....
25.
DEDIĆ A., CANCAR H.D., EDINA M. In-vitro antioxidant and antimicrobial activity of aerial parts of Prunus spinosa L. growing wild in Bosnia and Herzegovina. International Journal of Pharmaceutical Sciences Research. 12 (7), 2021.
26.
BABALAU-FUSS V., BĂRBUȚĂ A., ROȘU M., MUREȘAN A., CÂMPAN O., TUDOR M. Chemical and technological properties of blackthorn (Prunus spinosa) and rose hip (Rosa Canina) fruits grown wild in Cluj-Napoca area. Agriculture. 1 (1-2), 110, 2020.
27.
GIL M.I., TOMÁS-BARBERÁN F.A., HESS-PIERCE B., KADER A.A. Antioxidant capacities, phenolic compounds, carotenoids, and vitamin C contents of nectarine, peach, and plum cultivars from California. Journal of Agricultural and Food Chemistry. 50 (17), 2002. https://doi.org/10.1021/jf0201....
28.
NEGREAN O., FĂRCAȘ A., SOCACI S., CIONT C., MEDELEANU M., SIMON E., POP O. Extraction and characterization of bioactive compounds from Prunus spinosa L. fruits with potential in the development of edible films. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Food Science and Technology. 80 (2), 2023. https://doi.org/10.15835/buasv....
29.
ILHAN G. Sensory evaluation, biochemical, bioactive and antioxidant properties in fruits of wild blackthorn (Prunus spinosa L.) genotypes from Northeastern Türkiye. Horticulturae. 9 (9), 2023. https://doi.org/10.3390/hortic....
30.
LUNA-VÁZQUEZ F., IBARRA-ALVARADO C., ROJAS-MOLINA A., ROJAS-MOLINA J., YAHIA E., RIVERA-PASTRANA D., ROJAS-MOLINA A., ZAVALA-SÁNCHEZ Á.M. Nutraceutical value of black cherry Prunus Serotina Ehrh. fruits: antioxidant and antihypertensive properties. Molecules. 18 (12), 2013. https://doi.org/10.3390/molecu....
31.
YANG C.S., LANDAU J.M., HUANG M.-T., NEWMARK H.L. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annual Review of Nutrition. 21 (1), 2001. https://doi.org/10.1146/annure....
32.
LALL R., SYED D., ADHAMI V., KHAN M., MUKHTAR H. Dietary polyphenols in prevention and treatment of prostate cancer. International Journal of Molecular Sciences. 16 (2), 2015. https://doi.org/10.3390/ijms16....
33.
TARDÍO J., SÁNCHEZ-MATA M.D., MORALES R., MOLINA M., GARCÍA-HERRERA P., MORALES P., DÍEZ-MARQUÉS C., FERNÁNDEZ-RUIZ V., CÁMARA M., PARDO-DE-SANTAYANA M., MATALLANA-GONZÁLEZ M.C., RUIZ-RODRÍGUEZ B.M., SÁNCHEZ-MATA D., TORIJA-ISASA M.E., GUIL-GUERRERO J.L., BOUSSALAH N. Ethnobotanical and food composition monographs of selected Mediterranean wild edible plants. In Mediterranean Wild Edible Plants; Springer New York: New York, NY, 273, 2016. https://doi.org/10.1007/978-1-....
34.
BEI M.F., APAHIDEAN A.I., BUDĂU R., ROSAN C.A., POPOVICI R., MEMETE A.R., DOMOCOȘ D., VICAS S.I. An overview of the phytochemical composition of different organs of Prunus spinosa L., their health benefits and application in food industry. Horticulturae. 10 (1), 2023. https://doi.org/10.3390/hortic....
35.
CONDELLO M., MESCHINI S. Role of natural antioxidant products in colorectal cancer disease: a focus on a natural compound derived from Prunus spinosa, Trigno ecotype. Cells. 10 (12), 2021. https://doi.org/10.3390/cells1....
36.
KARAKAS N., OKUR M.E., OZTURK I., AYLA S., KARADAĞ A.E., POLAT D.Ç. Antioxidant activity and cytotoxic effects of Prunus spinosa L. fruit extract on various cancer cell lines. Medeniyet Medical Journal. 34 (3), 297, 2019. https://doi.org/10.5222/MMJ.20....
37.
GEGIU G., GRIGORIAN M. Contributions to the antimicrobial and antifungal study of the aqueous extract of Prunus spinosa L. Farmacia. 63 (3), 275, 2015.
38.
GEGIU G., BUCUR L., POPESCU A., RADU M.-D., MIHAI S., BADEA V. Studies on the phytochemical composition and antioxidant activity of a Prunus spinosa L. aqueous extract. Revista de Chimie. 71 (2), 2020. https://doi.org/10.37358/RC.20....
39.
KURU BERK S., TAS A., ORMAN E.., GUNDOGDU M., NECAS T., ONDRASEK I., KARATAS N., ERCISLI S. Agro-morphological and biochemical characterization of wild Prunus spinosa L. subsp. dasyphylla (Schur) Domin genotypes naturally grown in Western Black Sea Region of Turkey. Agronomy. 10 (11), 2020. https://doi.org/10.3390/agrono....
40.
CELIK F., GUNDOGDU M., ALP S., MURADOGLU F., ERCISLI S., GECER M.K., CANAN I. Determination of phenolic compounds, antioxidant capacity and organic acids contents of Prunus Domestica L., Prunus Cerasifera Ehrh. and Prunus spinosa L. fruits by HPLC. Acta Chromatographica. 29 (4), 2017. https://doi.org/10.1556/1326.2....
41.
DUMITRU C.N., MARIANA L., BUDACU C.C., MITEA G., RADU M.D., DUMITRU A.O., LUPOAE A., TATU A., TOPOR G. Balancing the oral redox state: endogenous and exogenous sources of reactive oxygen species and the antioxidant role of Lamiaceae and Asteraceae. Dentistry Journal (Basel). 13 (5), 222, 2025. https://doi.org/10.3390/dj1305....
42.
ŠAMEC D., DURGO K., GRÚZ J., KREMER D., KOSALEC I., PILJAC-ŽEGARAC J., SALOPEK-SONDI B. Genetic and phytochemical variability of six Teucrium Arduini L. populations and their antioxidant/prooxidant behaviour examined by biochemical, macromolecule and cell-based approaches. Food Chemistry. 186, 298, 2015. https://doi.org/10.1016/j.food....
43.
YOSHIOKA Y., OHISHI T., NAKAMURA Y., FUKUTOMI R., MIYOSHI N. Anti-cancer effects of dietary polyphenols via ROS-mediated pathway with their modulation of microRNAs. Molecules. 27 (12), 3816, 2022. https://doi.org/10.3390/molecu....
44.
KHAN H.Y., ZUBAIR H., FAISAL M., ULLAH M.F., FARHAN M., SARKAR F.H., AHMAD A., HADI S.M. Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action. Molecular Nutrition Food Research. 58 (3), 437, 2014. https://doi.org/10.1002/mnfr.2....
45.
YADAV E., YADAV P., KAMAL M.A., VERMA A. Polyphenols as modulators of oxidative stress in cancer disease. In Polyphenols-based Nanotherapeutics for Cancer Management; Springer Singapore: Singapore, 143, 2021. https://doi.org/10.1007/978-98....
46.
HADI S.M., ASAD S.F., SINGH S., AHMAD A. Putative mechanism for anticancer and apoptosis‐inducing properties of plant‐derived polyphenolic compounds. IUBMB Life. 50 (3), 167, 2000. https://doi.org/10.1080/152165....
47.
EGEA I., SÁNCHEZ-BEL P., ROMOJARO F., PRETEL M.T. Six edible wild fruits as potential antioxidant additives or nutritional supplements. Plant Foods for Human Nutrition. 65 (2), 2010. https://doi.org/10.1007/s11130....
48.
AKBARI B., BAGHAEI-YAZDI N., BAHMAIE M., MAHDAVI ABHARI F. The role of plant-derived natural antioxidants in reduction of oxidative stress. BioFactors. 48 (3), 2022. https://doi.org/10.1002/biof.1....
49.
BASU A., SCHELL J., SCOFIELD R.H. Dietary fruits and arthritis. Food Function. 9 (1), 70, 2018. https://doi.org/10.1039/C7FO01....
50.
RAWAT P., SINGH P.K., KUMAR V. Indian tropical fruits and role of their bioactive compounds against human diseases. In Medicinal Plants; CRC Press: Boca Raton: Taylor & Francis, 115, 2019. https://doi.org/10.1201/978042....
51.
MUSCHIETTI L.V., ULLOA J.L., REDKO F.D.C. The role of flavonoids as modulators of inflammation and on cell signaling pathways. In Natural Products as Source of Molecules with Therapeutic Potential; Springer International Publishing: Cham, 159, 2018. https://doi.org/10.1007/978-3-....
52.
OBEAGU E. A review on free radicals and antioxidants. International Journal of Current Research in Medical Sciences. 4 (2), 123, 2018.
53.
MITEA G., SCHRÖDER V., IANCU I.M., MIREȘAN H., IANCU V., BUCUR L.A., BADEA F.C. Molecular targets of plant-derived bioactive compounds in oral squamous cell carcinoma. Cancers (Basel). 16 (21), 3612, 2024. https://doi.org/10.3390/cancer....
54.
MITEA G., IANCU I.M., SCHRÖDER V., ROȘCA A.C., IANCU V., CREȚU R.M., MIREȘAN H. Therapeutic potential of Prunus species in gastrointestinal oncology. Cancers (Basel). 17 (6), 938, 2025. https://doi.org/10.3390/cancer....
55.
JONES H.R., ROBB C.T., PERRETTI M., ROSSI A.G. The role of neutrophils in inflammation resolution. Seminars in Immunology. 28 (2), 137, 2016. https://doi.org/10.1016/j.smim....
56.
RAWAT K., SHRIVASTAVA A. Neutrophils as emerging protagonists and targets in chronic inflammatory diseases. Inflammation Research. 71 (12), 2022. https://doi.org/10.1007/s00011....
57.
SOEHNLEIN O., STEFFENS S., HIDALGO A., WEBER C. Neutrophils as protagonists and targets in chronic inflammation. Nature Reviews Immunology. 17 (4), 2017. https://doi.org/10.1038/nri.20....
58.
EL-BENNA J., HURTADO-NEDELEC M., GOUGEROT-POCIDALO M.-A., DANG P.M.-C. Effects of venoms on neutrophil respiratory burst: a major inflammatory function. Journal of Venomous Animals and Toxins including Tropical Diseases. 27, 2021. https://doi.org/10.1590/1678-9....
59.
MANOHARAN R.R., PRASAD A., POSPÍŠIL P., KZHYSHKOWSKA J. ROS signaling in innate immunity via oxidative protein modifications. Frontiers in Immunology. 15, 2024. https://doi.org/10.3389/fimmu.....
60.
MAIER-BEGANDT D., ALONSO-GONZALEZ N., KLOTZ L., ERPENBECK L., JABLONSKA J., IMMLER R., HASENBERG A., MUELLER T.T., HERRERO-CERVERA A., ARANDA-PARDOS I., FLORA K., ZARBOCK A., BRANDAU S., SCHULZ C., SOEHNLEIN O., STEIGER S. Neutrophils-biology and diversity. Nephrology Dialysis Transplantation. 39 (10), 2024. https://doi.org/10.1093/ndt/gf....
61.
BOURGONJE A.R., FEELISCH M., FABER K.N., PASCH A., DIJKSTRA G., VAN GOOR H. Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease. Trends in Molecular Medicine. 26 (11), 2020. https://doi.org/10.1016/j.molm....
62.
MURO P., ZHANG L., LI S., ZHAO Z., JIN T., MAO F., MAO Z. The emerging role of oxidative stress in inflammatory bowel disease. Frontiers in Endocrinology. 15, 2024. https://doi.org/10.3389/fendo.....
63.
TIWARI B.K., PANDEY K.B., ABIDI A.B., RIZVI S.I. Markers of oxidative stress during diabetes mellitus. Journal of Biomarkers. 378790, 2013. https://doi.org/10.1155/2013/3....
64.
ALI A., KUMAR M., SRIVASTAVA N., KHAN M.M., KHAN M.A. Free radicals and diabetes mellitus. International Journal of Pharmaceutical Sciences and Medicine. 8 (3), 2023. https://doi.org/10.47760/ijpsm....
65.
GOYCHEVA P., PETKOVA-PARLAPANSKA K., GEORGIEVA E., KARAMALAKOVA Y., NIKOLOVA G. Biomarkers of oxidative stress in diabetes mellitus with diabetic nephropathy complications. International Journal of Molecular Sciences. 24 (17), 2023. https://doi.org/10.3390/ijms24....
66.
JHA J.C., HO F., DAN C., JANDELEIT-DAHM K.A. A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes. Clinical Science. 132 (16), 2018. https://doi.org/10.1042/CS2017....
67.
SABATINI L., FRATERNALE D., DI GIACOMO B., MARI M., ALBERTINI M.C., GORDILLO B., ROCCHI M.B.L., SISTI D., COPPARI S., SEMPRUCCI F., GUIDI L., COLOMBA M. Chemical composition, antioxidant, antimicrobial and anti-inflammatory activity of Prunus spinosa L. fruit ethanol extract. Journal of Functional Foods. 67, 2020. https://doi.org/10.1016/j.jff.....
68.
HASHIM M., ALI S.H. Biomarkers of oxidative stress in diabetic microvascular complications review article. Iraqi Journal of Pharmaceutical Sciences. 33 (3), 2024. https://doi.org/10.31351/vol33....
69.
ALARCÓN R., PARDO-DE-SANTAYANA M., PRIESTLEY C., MORALES R., HEINRICH M. Medicinal and local food plants in the south of Alava (Basque Country, Spain). Journal of Ethnopharmacology. 176, 2015. https://doi.org/10.1016/j.jep.....
70.
KOTSOU K., STOIKOU M., ATHANASIADIS V., CHATZIMITAKOS T., MANTINIOTOU M., SFOUGARIS A.I., LALAS S.I. Enhancing antioxidant properties of Prunus spinosa fruit extracts via extraction optimization. Horticulturae. 9 (8), 2023. https://doi.org/10.3390/hortic....
71.
RUIZ-RODRÍGUEZ B.M., DE ANCOS B., SÁNCHEZ-MORENO C., FERNÁNDEZ-RUIZ V., DE CORTES SÁNCHEZ-MATA M., CÁMARA M., TARDÍO J. Wild blackthorn (Prunus spinosa L.) and hawthorn (Crataegus Monogyna Jacq.) fruits as valuable sources of antioxidants. Fruits. 69 (1), 2014. https://doi.org/10.1051/fruits....
72.
SIKORA E., BIENIEK M.I., BORCZAK B. Composition and antioxidant properties of fresh and frozen stored blackthorn fruits (Prunus spinosa L.). Acta Scientiarum Polonorum Technologia Alimentaria. 12 (4), 2013.
73.
FRATERNALE D., GIAMPERI L., BUCCHINI A., SESTILI P., PAOLILLO M., RICCI D. Prunus spinosa fresh fruit juice: antioxidant activity in cell-free and cellular systems. Natural Product Communications. 4 (12), 2009. https://doi.org/10.1177/193457....
74.
PINACHO R., CAVERO R.Y., ASTIASARÁN I., ANSORENA D., CALVO M.I. Phenolic compounds of blackthorn (Prunus spinosa L.) and influence of in vitro digestion on their antioxidant capacity. Journal of Functional Foods. 19, 2015. https://doi.org/10.1016/j.jff.....
75.
PANDA L., DUARTE-SIERRA A. Recent advancements in enhancing antimicrobial activity of plant-derived polyphenols by biochemical means. Horticulturae. 8 (5), 401, 2022. https://doi.org/10.3390/hortic....
76.
DAVIDOVA S., GALABOV A.S., SATCHANSKA G. Antibacterial, antifungal, antiviral activity, and mechanisms of action of plant polyphenols. Microorganisms. 12 (12), 2502, 2024. https://doi.org/10.3390/microo....
77.
MANDAL M.K., DOMB A.J. Antimicrobial activities of natural bioactive polyphenols. Pharmaceutics. 16 (6), 718, 2024. https://doi.org/10.3390/pharma....
78.
SOTELO D.I., CASAS F.N., CAMELO M.G. BOROJÓ (Borojoa Patinoi): source of polyphenols with antimicrobial activity. Vitae. 17 (3), 329, 2010. https://doi.org/10.17533/udea.....
79.
PATRA B., DAS N., SHAMIM M.Z., MOHANTA T.K., MISHRA B., MOHANTA Y.K. Dietary natural polyphenols against bacterial and fungal infections: an emerging gravity in health care and food industry. In Bioprospecting of Tropical Medicinal Plants; Springer Nature Switzerland: Cham, 807, 2023. https://doi.org/10.1007/978-3-....
80.
DHRISHA J.A., GHANA PRIYA K. Review on novel approach to food shelf-life extension: fruit peel polyphenols as eco-friendly photosensitizers. International Journal of Science and Advanced Technology. 16 (1), 2025. https://doi.org/10.71097/IJSAT....
81.
YANG X., JIANG X. Antifungal activity and mechanism of tea polyphenols against Rhizopus Stolonifer. Biotechnology Letters. 37 (7), 1463, 2015. https://doi.org/10.1007/s10529....
82.
VRINDA, NARANG G., PANDEY G., SINGH P., KUMARI K. Polyphenols as antimicrobial (disinfectant and pest control) applications. In Science and Engineering of Polyphenols; Wiley, 416, 2024. https://doi.org/10.1002/978139....
83.
SHAHZAD M., SHERRY L., RAJENDRAN R., EDWARDS C.A., COMBET E., RAMAGE G. Inhibitory effect of plant (poly)phenolics on growth and biofilm formation by Candida albicans. Proceedings of the Nutrition Society. 73 (OCE1), 2014. https://doi.org/10.1017/S00296....
84.
GÓMEZ-MALDONADO D., LOBATO-CALLEROS C., AGUIRRE-MANDUJANO E., LEYVA-MIR S.G., ROBLES-YERENA L., VERNON-CARTER E.J. Antifungal activity of mango kernel polyphenols on mango fruit infected by anthracnose. LWT-Food Science and Technology. 126, 2020. https://doi.org/10.1016/j.lwt.....
85.
SMULLEN J., KOUTSOU G.A., FOSTER H.A., ZUMBÉ A., STOREY D.M. The antibacterial activity of plant extracts containing polyphenols against Streptococcus mutans. Caries Research. 41 (5), 2007. https://doi.org/10.1159/000104....
86.
VELICKOVIC I., ZIZAK Z., RAJCEVIC N., IVANOV M., SOKOVIC M., MARIN P., GRUJIC S. Examination of the polyphenol content and bioactivities of Prunus spinosa L. fruit extracts. Archives of Biological Sciences. 72 (1), 2020. https://doi.org/10.2298/ABS191....
87.
KUMARASAMY Y., COX P.J., JASPARS M., NAHAR L., SARKER S.D. Comparative studies on biological activities of Prunus Padus and P. Spinosa. Fitoterapia. 75 (1), 2004. https://doi.org/10.1016/j.fito....
88.
RADOVANOVIĆ B., ANĐELKOVIĆ S., RADOVANOVIĆ A., ANĐELKOVIĆ M. Antioxidant and antimicrobial activity of polyphenol extracts from wild berry fruits grown in Southeast Serbia. Tropical Journal of Pharmaceutical Research. 12 (5), 2013. https://doi.org/10.4314/tjpr.v....
89.
MARCHELAK A., OWCZAREK A., MATCZAK M., PAWLAK A., KOLODZIEJCZYK-CZEPAS J., NOWAK P., OLSZEWSKA M.A. Bioactivity potential of Prunus spinosa L. flower extracts: phytochemical profiling, cellular safety, pro-inflammatory enzymes inhibition and protective effects against oxidative stress in vitro. Frontiers in Pharmacology. 8, 2017. https://doi.org/10.3389/fphar.....
90.
MITEA G., IANCU I.M., BLEBEA N.M., BUCUR L.A., SCHRODER V., BADEA V., BADEA C.F., NUCA C., RADU M.D., IANCU V. Cotinine and IL-6 - biomarkers for estimating pharmacological processes in various forms of periodontitis. In 2021 International Conference on e-Health and Bioengineering (EHB); IEEE, 1, 2021. https://doi.org/10.1109/EHB528....
91.
COLOMBA M., BENEDETTI S., FRATERNALE D., GUIDARELLI A., COPPARI S., FRESCHI V., CRINELLI R., KASS G.E.N., GORASSINI A., VERARDO G., ROSELLI C., MELI M.A., DI GIACOMO B., ALBERTINI M.C. Nrf2-mediated pathway activated by Prunus spinosa L. (Rosaceae) fruit extract: bioinformatics analyses and experimental validation. Nutrients. 15 (9), 2023. https://doi.org/10.3390/nu1509....
92.
COPPARI S., COLOMBA M., FRATERNALE D., BRINKMANN V., ROMEO M., ROCCHI M.B.L., DI GIACOMO B., MARI M., GUIDI L., RAMAKRISHNA S., VENTURA N., ALBERTINI M.C. Antioxidant and anti-inflammaging ability of prune (Prunus spinosa L.) extract result in improved wound healing efficacy. Antioxidants. 10 (3), 2021. https://doi.org/10.3390/antiox....
93.
BRGLEZ MOJZER E., KNEZ HRNČIČ M., ŠKERGET M., KNEZ Ž., BREN U. Polyphenols: extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Molecules. 21 (7), 2016. https://doi.org/10.3390/molecu....
CITATIONS (1):
1.
Optimal Method Selection for Extracting Bioactive Compounds from Prunus spinosa L. Fruits and Evaluating the Antimicrobial Activity of the Resulting Extract
Oksana Barna, Nataliia Aponchuk, Lidiya Romanyuk, Mariia Hrabovets, Mariana Fedorovska, Mariia Shanaida
Biomedical & Pharmacology Journal
Oksana Barna, Nataliia Aponchuk, Lidiya Romanyuk, Mariia Hrabovets, Mariana Fedorovska, Mariia Shanaida
Biomedical & Pharmacology Journal
Share
RELATED ARTICLE
| eISSN: | 2083-5906 |
| ISSN: | 1230-1485 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
