The aim of this quantitative research is to determine the perception and actual knowledge of secondary school students in the Belgrade region with respect to earthquakes as a natural disaster and security threat, and to identify the factors that influence their knowledge and perceptions. The authors used a method of surveying students to identify and describe the factors that influence student knowledge and perceptions about earthquakes. For the purpose of this research, a sample of 3,063 students was drawn from the total population of secondary school students in Belgrade (65,561 students), which equates to 4.67% of the population. The results show that the sources of information on natural disasters and their threatening consequences influence the perceptions of secondary school students. In view of the evident lack of education about natural disasters in Serbia, the results of this study can be used when creating a strategy for educational programs. This research is the first step in developing and realizing a future strategy for natural disaster management by informing and including public (school population), scientific, and administrative communities in the process.