The aim of our current research was to study the effects of Vitamins C and E separately and jointly in reducing the amount of accumulated heavy metals in different tissues of common carp exposed to heavy metals. After acclimatization the fish were divided into two groups: the control group and the group subjected to heavy metal exposure. The fish were exposed to a mixture of heavy metals containing: lead acetate 0.3 mg/l, cadmium chloride 0.4 mg/l and mercuric chloride 0.001 mg/l. After exposure, there was a significant increase (p<0.01) in metal accumulation in fish tissues compared with the control group. Exposed fish were then divided into three groups: one received only vitamin C, the other only vitamin E and last group received a combination of vitamins C and E. Based on the present results, the order of accumulated heavy metals in investigated tissues of all groups is gills> liver> muscles> plasma. Supplementation of vitamins C and E either alone or jointly had significantly decreased (p<0.01; p<0.05) levels of accumulated heavy metals in investigated tissues compared to the control and exposed groups. Supplementation of vitamin C and E jointly showed more chelating ability compared with the effect of vitamins C and E, separately.