This study focuses on the identification and characterization of Ficopomatus shenzhensis, a species of serpulid worm found in shrimp ponds of the Saigon River in Vietnam. The aim of the research is to understand the species’ characteristics and find potential solutions to control its growth in aquaculture ponds. The methodology involved sample collection from shrimp ponds in the Can Gio biosphere reserve, morphological examination, and DNA-based species identification using the 18S ribosomal RNA gene. The results revealed the presence of Ficopomatus shenzhensis in the study area, and its morphological features were described. Additionally, DNA sequencing confirmed its identity, and phylogenetic analysis showed a close relationship with Ficopomatus shenzhensis from previous studies. The distribution of Ficopomatus shenzhensis was found to be widespread in the southern coastal provinces of Vietnam, suggesting a long-standing invasion. The species likely arrived through ballast water transportation. The ecological observations indicate that Ficopomatus shenzhensis attaches to various materials and requires high levels of dissolved oxygen. The study highlights the need for monitoring and further research on the distribution and impact of Ficopomatus shenzhensis in coastal lagoons of Vietnam.